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超声引导下椎旁导管置入治疗肋骨骨折镇痛的安全性、并发症及临床转归:一项单中心回顾性观察研究。

Safety, complications and clinical outcome after ultrasound-guided paravertebral catheter insertion for rib fracture analgesia: a single-centre retrospective observational study.

机构信息

Royal Victoria Infirmary, Newcastle upon Tyne, UK.

James Cook University Hospital, Middlesbrough, UK.

出版信息

Anaesthesia. 2019 May;74(5):594-601. doi: 10.1111/anae.14580. Epub 2019 Jan 27.

DOI:10.1111/anae.14580
PMID:30687939
Abstract

Rib fractures are associated with significant morbidity and mortality. Ultrasound-guided thoracic paravertebral catheter insertion has been described for the management of pain secondary to rib fractures. We conducted a retrospective observational study of all patients with rib fractures who had a paravertebral catheter inserted for analgesia provision over a 4-year period. Data from the Trauma Audit and Research Network were used to compare patients with rib fractures who were managed with paravertebral catheters to those managed with systemic analgesia. A total of 314 consecutive paravertebral catheters were inserted in 290 patients. Five (1.9%) catheters were removed due to ineffective analgesia. Other minor complications occurred in three cases (0.96%). The proportion of rib fracture patients managed with paravertebral catheters increased from 31/200 (15.5%) in the first year of study to 81/168 (48.2%) in the fourth; over this time-period the observed:predicted mortality ratio fell from 1.04 to 0.66. Proportional hazard regression with and without propensity score matching demonstrated a reduction in mortality associated with paravertebral catheter use, but this became statistically non-significant when time-dependent analysis was used. Paravertebral catheters are a safe and effective technique for rib fracture analgesia; however, our data were insufficient to demonstrate any improvement in mortality.

摘要

肋骨骨折与较高的发病率和死亡率相关。超声引导下胸椎旁导管插入术已被用于治疗肋骨骨折引起的疼痛。我们对 4 年内所有因镇痛而接受肋间神经阻滞导管插入术的肋骨骨折患者进行了回顾性观察性研究。使用创伤审核和研究网络的数据,将接受肋间神经阻滞导管治疗的肋骨骨折患者与接受全身镇痛治疗的患者进行了比较。共连续插入了 290 名患者的 314 个肋间神经阻滞导管。由于镇痛效果不佳,有 5 个(1.9%)导管被移除。另外 3 例发生轻微并发症(0.96%)。接受肋间神经阻滞导管治疗的肋骨骨折患者比例从研究第一年的 31/200(15.5%)增加到第四年的 81/168(48.2%);在此期间,观察到的死亡率预测比从 1.04 降至 0.66。无论是否进行倾向评分匹配的比例风险回归均显示,肋间神经阻滞导管的使用与死亡率降低相关,但当使用时间依赖性分析时,这一结果不再具有统计学意义。肋间神经阻滞导管是治疗肋骨骨折疼痛的一种安全有效的技术;然而,我们的数据不足以证明死亡率有任何改善。

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