Israel Defense Forces, Medical Corps, Ramat Gan, Israel.
Department of Internal Medicine, Rambam Health Care Campus, Haifa, Israel.
Aliment Pharmacol Ther. 2019 Mar;49(5):556-563. doi: 10.1111/apt.15160. Epub 2019 Jan 27.
The incidence and prevalence trends of inflammatory bowel disease (IBD) vary between developed and developing countries.
To investigate the prevalence and associated sociodemographic factors of IBD in Israeli Jewish adolescents METHODS: The files of the army medical corps were reviewed for adolescents recruited in 2002-2016 with confirmed IBD. Covariate data included birth date, patient and parental country of birth, number of children in the household, age at diagnosis, and socioeconomic status. Findings were compared with the remaining recruits without IBD.
Of the 1,144,213 adolescents recruited, 2372 (0.2%) had IBD (Crohn's disease, 68%). Median age of the cohort was 17.1 years (interquartile range, 16.9-17.3). Over the study period, the annual point prevalence per 100,000 examinees significantly increased: total IBD, 58 to 373; Crohn's disease, 42 to 425; ulcerative colitis, 16 to 128. Mean age at IBD diagnosis decreased from 15.0 ± 2.8 years in 2002-2008 to 14.3 ± 3.1 years in 2009-2016 (P < 0.0001). Significance was maintained on separate analyses of Crohn's disease and ulcerative colitis. Both diseases were significantly less prevalent in subjects from families with at least one parent born in a developing country and ≥3 children. There was a significant association of lower socioeconomic status with lower prevalence of Crohn's disease (odds ratio 0.41, 95% confidence interval, 0.31-0.54) and ulcerative colitis (odds ratio 0.25, 95% confidence interval, 0.15-0.42).
The point prevalence of Crohn's disease and ulcerative colitis in Israeli Jewish adolescents increased six-fold and eight-fold, respectively, over 15 years along with a decrease in age at diagnosis.
炎症性肠病（IBD）的发病率和患病率趋势在发达国家和发展中国家之间存在差异。
调查以色列犹太青少年 IBD 的患病率及相关社会人口学因素。
对 2002-2016 年期间入伍并确诊 IBD 的青少年的军队医疗团档案进行了回顾性分析。协变量数据包括出生日期、患者和父母的出生国、家庭中儿童的数量、诊断时的年龄以及社会经济状况。并将这些结果与未患有 IBD 的其余新兵进行了比较。
在 1144213 名入伍的青少年中，有 2372 人（0.2%）患有 IBD（克罗恩病，68%）。队列的中位年龄为 17.1 岁（四分位间距，16.9-17.3）。在研究期间，每 10 万名受检者的年度时点患病率显著增加：总 IBD 从 58 例/10 万增加到 373 例/10 万；克罗恩病从 42 例/10 万增加到 425 例/10 万；溃疡性结肠炎从 16 例/10 万增加到 128 例/10 万。IBD 诊断的平均年龄从 2002-2008 年的 15.0±2.8 岁降至 2009-2016 年的 14.3±3.1 岁（P<0.0001）。克罗恩病和溃疡性结肠炎的单独分析结果均具有统计学意义。来自父母至少一方出生在发展中国家且有≥3 个孩子的家庭的受试者中，这两种疾病的患病率显著较低。社会经济地位较低与克罗恩病（比值比 0.41，95%置信区间，0.31-0.54）和溃疡性结肠炎（比值比 0.25，95%置信区间，0.15-0.42）的低患病率显著相关。
在 15 年的时间里，以色列犹太青少年的克罗恩病和溃疡性结肠炎的点患病率分别增加了六倍和八倍，同时诊断时的年龄也有所下降。
