Stulman Mira, Focht Gili, Loewenberg Weisband Yiska, Greenfeld Shira, Ben Tov Amir, Ledderman Natan, Matz Eran, Paltiel Ora, Odes Shmuel, Dotan Iris, Benchimol Eric Ian, Turner Dan
The Juliet Keiden Institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9103102, Israel.
Braun School of Public Health and Community Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9574869, Israel.
World J Methodol. 2023 Dec 20;13(5):475-483. doi: 10.5662/wjm.v13.i5.475.
Israel has a high rate of Jewish immigration and a high prevalence of inflammatory bowel disease (IBD).
To compare IBD prevalence in first-generation immigrants Israel-born Jews.
Patients with a diagnosis of IBD as of June 2020 were included from the validated epi-IIRN (Israeli IBD Research Nucleus) cohort that includes 98% of the Israeli population. We stratified the immigration cohort by IBD risk according to country of origin, time period of immigration, and age group as of June 2020.
A total of 33544 patients were ascertained, of whom 18524 (55%) had Crohn's disease (CD) and 15020 (45%) had ulcerative colitis (UC); 28394 (85%) were Israel-born and 5150 (15%) were immigrants. UC was more prevalent in immigrants (2717; 53%) than in non-immigrants (12303, 43%, < 0.001), especially in the < 1990 immigration period. After adjusting for age, longer duration in Israel was associated with a higher point prevalence rate in June 2020 (high-risk origin: Immigration < 1990: 645.9/100000, ≥ 1990: 613.2/100000, = 0.043; intermediate/low-risk origin: < 1990: 540.5/100000, ≥ 1990: 192.0/100000, < 0.001). The prevalence was higher in patients immigrating from countries with high risk for IBD (561.4/100000) than those originating from intermediate-/low-risk countries (514.3/100000; < 0.001); non-immigrant prevalence was 528.9/100000.
Lending support to the environmental effect on IBD etiology, we found that among immigrants to Israel, the prevalence of IBD increased with longer time since immigration, and was related to the risk of IBD in the country of origin. The UC rate was higher than that of CD only in those immigrating in earlier time periods.
以色列犹太移民率高，炎症性肠病（IBD）患病率也高。
比较第一代移民与在以色列出生的犹太人的IBD患病率。
从经过验证的epi-IIRN（以色列IBD研究核心）队列中纳入截至2020年6月诊断为IBD的患者，该队列涵盖了98%的以色列人口。我们根据原籍国、移民时间段和截至2020年6月的年龄组，将移民队列按IBD风险进行分层。
共确定了33544例患者，其中18524例（55%）患有克罗恩病（CD），15020例（45%）患有溃疡性结肠炎（UC）；28394例（85%）在以色列出生，5150例（15%）为移民。UC在移民中（2717例；53%）比非移民中（12303例，43%，P<0.001）更普遍，尤其是在1990年以前的移民时期。在调整年龄后，在以色列居住时间越长，2020年6月的时点患病率越高（高风险原籍国：移民时间<1990年：645.9/100000，≥1990年：613.2/100000，P=0.043；中/低风险原籍国：<1990年：540.5/100000，≥1990年：192.0/100000，P<0.001）。从IBD高风险国家移民的患者患病率（561.4/100000）高于来自中/低风险国家的患者（514.3/100000；P<0.001）；非移民患病率为528.9/100000。
支持环境因素对IBD病因学影响的观点，我们发现，在移民到以色列的人群中，IBD患病率随移民后时间延长而增加，且与原籍国的IBD风险相关。仅在较早时期移民的人群中，UC发病率高于CD。
