Department of Chemistry, Sardar Bahadur Khan Women's University, Quetta, Pakistan.
King Abdulaziz University, P.O. Box 80203, Jeddah, Saudi Arabia, 21589.
Nat Prod Res. 2020 Nov;34(22):3199-3204. doi: 10.1080/14786419.2018.1556657. Epub 2019 Jan 28.
Our continuation on the bio-assay guided isolation from Linn. led to the discovery of a new dibezofuran type phloroglucinol 1,1'-(1,3,7,9-tetrahydroxydibenzo[b,d]furan-2,8-diyl)bis(ethan-1-one) . The structure was established through detailed spectroscopic studies including one and two dimensional NMR spectroscopy and electrospray ionization high resolution mass spectrometer (ESI-HRMS). The crude acetone extract from (AMA), dichloromethane fraction (DCM), and the isolated pure compound were tested against pathogenic bacteria. Compound displayed higher antibacterial activity against the Gram-positive and Gram-negative and respectively as compared to the crude extract and fractions.
我们继续对 Linn 进行生物测定指导分离，发现了一种新的二苯并呋喃型间苯三酚 1,1'-(1,3,7,9-四羟基二苯并[b,d]呋喃-2,8-二基)双(乙醇-1-酮)。通过详细的光谱研究，包括一维和二维 NMR 光谱和电喷雾电离高分辨率质谱仪（ESI-HRMS），确定了其结构。从（AMA）的粗丙酮提取物、二氯甲烷部分（DCM）和分离得到的纯化合物都对抗菌活性进行了测试。与粗提物和馏分相比，化合物对革兰氏阳性菌和革兰氏阴性菌和分别显示出更高的抗菌活性。
