Dipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche-DiSTABiF, Università degli Studi della Campania "Luigi Vanvitelli", Via Vivaldi 43, 81100 Caserta, Italy.
Allelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO), School of Science, University of Cadiz, Campus de Excelencia Internacional (ceiA3), C/ República Saharaui n° 7, 11510 Puerto Real, Spain.
Molecules. 2022 Oct 21;27(20):7109. doi: 10.3390/molecules27207109.
Myrtaceae family is a continuous source of antimicrobial agents. In the search for novel antimicrobial agents against species, bioactive fractions of L., growing in the Sardinia island (Italy) have been investigated. Their phytochemical analysis led us to isolate and characterize four alkylphloroglucinol glycosides (-), three of them gallomyrtucommulones G-H (,), and myrtucommulonoside () isolated and characterized for the first time. The structures of the new and known compounds, endopreroxide G3 (), myricetin-3--glycosides (,) were determined based on the spectroscopic evidence including 1D-/2D-NMR and HR-MS spectrometry. Enriched fractions as well as pure compounds were tested for their antimicrobial activity by broth micro-dilution assay against and Results reported herein demonstrated that gallomyrtucommulone G () showed a selective antimicrobial activity against both strains (ATCC 29213 and 43300) until 16 μg/mL while gallomyrtucommulone D () showed the best growth inhibition value at 64 μg/mL.
桃金娘科是抗菌剂的持续来源。在寻找针对 种的新型抗菌剂的过程中，研究了生长在撒丁岛（意大利）的 L. 的生物活性部分。它们的植物化学分析导致我们分离并表征了四个烷基间苯三酚糖苷（-），其中三个是首次分离和表征的gallomyrtucommulones G-H（，）和 myrtucommulonoside（）。基于包括 1D-/2D-NMR 和 HR-MS 光谱在内的光谱证据，确定了新的和已知化合物，内过氧化物 G3（），杨梅素-3--糖苷（，）的结构。富化部分和纯化合物通过肉汤微量稀释法测定对 和 的抗菌活性。本文报道的结果表明，gallomyrtucommulone G（）对两种 株（ATCC 29213 和 43300）均具有选择性抗菌活性，直到 16 μg/mL，而 gallomyrtucommulone D（）在 64 μg/mL 时显示出最佳的生长抑制值。
