Department of Diabetes, Epigenetics in Human Health and Disease Laboratory, Monash University, Melbourne, VIC, Australia.
Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
J Mol Cell Cardiol. 2019 Mar;128:129-133. doi: 10.1016/j.yjmcc.2019.01.019. Epub 2019 Jan 25.
Under the seeming disorder of "junk" sequences the last decade has seen developments in our understanding of non-coding RNA's (ncRNAs). It's a complex revised order and nowhere is this more relevant than in the developing heart whereby old rules have been set aside to make room for new ones. The development of the mammalian heart has been studied at the genetic and cellular level for several decades because these areas were considered ideal control points. As such, detailed mechanisms governing cell lineages are well described. Emerging evidence suggests a complex new order regulated by epigenetic mechanisms mark cardiac cell lineage. Indeed, molecular cardiologists are in the process of shedding light on the roles played by ncRNAs, nucleic acid methylation and histone/chromatin modifications in specific pathologies of the heart. The aim of this article is to discuss some of the recent advances in the field of cardiovascular epigenetics that are related to direct cell reprogramming and repair. As such, we explore ncRNAs as nodes regulating signaling networks and attempt to make sense of regulatory disorder by reinforcing the importance of epigenetic components in the developmental program.
在看似无序的“垃圾”序列中，过去十年我们对非编码 RNA(ncRNAs)的理解有了新的进展。这是一个复杂的修订秩序，在发育中的心脏中最为明显，旧规则被搁置，为新规则让路。几十年来，人们一直在基因和细胞水平上研究哺乳动物心脏的发育，因为这些领域被认为是理想的控制点。因此，控制细胞谱系的详细机制得到了很好的描述。新出现的证据表明，一种由表观遗传机制调控的复杂新秩序标志着心脏细胞谱系。事实上，分子心脏病学家正在揭示 ncRNAs、核酸甲基化和组蛋白/染色质修饰在心脏特定病理中的作用。本文的目的是讨论心血管表观遗传学领域的一些最新进展，这些进展与直接细胞重编程和修复有关。因此，我们将 ncRNAs 作为调节信号网络的节点进行研究，并试图通过强调表观遗传成分在发育程序中的重要性来理解调控紊乱。
