State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
Fitoterapia. 2019 Mar;133:186-192. doi: 10.1016/j.fitote.2019.01.014. Epub 2019 Jan 25.
Eight new triterpenoid saponins (1-8), were isolated from the roots of Glycyrrhiza uralensis Fisch., together with 10 known triterpenoid saponins (9-18). Their structures were determined by analysis of their spectroscopic data and comparison with the reference. All of the compounds were evaluated for their antioxidant effects in the in vitro assay. Compounds 2 and 8 showed significant antioxidant activities against Fe/cysteine-induced liver microsomal lipid peroxidation at 0.1 μM.
从甘草根中分离得到了 8 种新的三萜皂苷（1-8），同时还分离得到了 10 种已知的三萜皂苷（9-18）。通过分析其光谱数据并与参考文献进行比较，确定了它们的结构。所有化合物均在体外测定其抗氧化作用。在 0.1μM 时，化合物 2 和 8 对 Fe/半胱氨酸诱导的肝微粒体脂质过氧化具有显著的抗氧化活性。
