School of Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China.
Chin J Nat Med. 2021 Jan;19(1):63-69. doi: 10.1016/S1875-5364(21)60007-9.
Two new triterpenoid saponins, ardisicrenoside R and S (1 and 2), and one new phenylpropanoid glycoside, ardicrephenin (3), along with five known compounds (4-8), were isolated from roots of Ardisia crenata. Their structures were elucidated on the basis of NMR spectroscopic data and chemical methods. Compounds 2-7 were evaluated for their cytotoxic activities against A549, MCF-7, HepG2 and MDA-MB-231 cell lines by MTT assay. Ardicrenin (6) showed significant cytotoxicity, with IC values of 1.17 ± 0.01, 1.19 ± 0.06, 3.52 ± 0.23, and 16.61 ± 1.02 μmol·L, respectively.
从紫金牛属植物紫金牛根部分离得到两个新的三萜皂苷，ardisicrenoside R 和 S（1 和 2），以及一个新的苯丙素糖苷ardicrephenin（3），以及 5 个已知化合物（4-8）。基于 NMR 谱数据和化学方法阐明了它们的结构。通过 MTT 法测定了化合物 2-7 对 A549、MCF-7、HepG2 和 MDA-MB-231 细胞系的细胞毒性。Ardicrenin（6）表现出显著的细胞毒性，其 IC 值分别为 1.17±0.01、1.19±0.06、3.52±0.23 和 16.61±1.02 μmol·L。
