使用 Addenbrooke 认知测验检测精神分裂症患者的认知障碍。
Detecting cognitive impairment in patients with schizophrenia with the Addenbrooke's Cognitive Examination.
机构信息
Department of Psychiatry and Department of Clinical Epidemiology, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.
Division of Psychiatry, Thammasat University Hospital, Pathumthani, Thailand.
出版信息
Asian J Psychiatr. 2019 Feb;40:19-22. doi: 10.1016/j.ajp.2019.01.006. Epub 2019 Jan 17.
OBJECTIVE
To assess the feasibility of the Addenbrooke's Cognitive Examination III (ACE) in detecting cognitive deficits in people with schizophrenia and to examine the profile of cognitive impairments.
METHODS
There were 32 participants with schizophrenia and 32 normal controls were carried out at Thammasat University Hospital, Thailand. They were matched 1:1 using comparable age and educational level. All participants completed the ACE.
RESULTS
Schizophrenia patients had lower mean totals in their ACE scores than normal controls [82.9(8.4) vs 89.6(6.1), p < 0.001]. Analysis of the individual cognitive subdomains demonstrated that patients performed significantly worse than normal controls on three subdomains: attention (p 0.007), memory (p 0.003) and verbal fluency (p 0.018). There were no statistically significant differences in the language (p 0.223) and visuospatial ability domains (p 0.055).
CONCLUSIONS
The ACE can detect the cognitive deficits in people with schizophrenia. They had a lower cognitive function compared to the normal controls.
目的
评估 Addenbrooke 认知测验第三版（ACE）在检测精神分裂症患者认知缺陷方面的可行性，并研究认知损伤的特征。
方法
在泰国玛希隆大学医院共纳入 32 名精神分裂症患者和 32 名正常对照者，采用年龄和教育程度相匹配的 1:1 方法进行匹配。所有参与者均完成 ACE 测验。
结果
精神分裂症患者的 ACE 总评分均值明显低于正常对照组[82.9（8.4）分比 89.6（6.1）分，p<0.001]。对个体认知子领域的分析显示，患者在注意力（p<0.007）、记忆（p<0.003）和言语流畅性（p<0.018）三个子领域的表现明显差于正常对照组。在语言（p=0.223）和视空间能力领域（p=0.055），两组间无统计学差异。
结论
ACE 可检测精神分裂症患者的认知缺陷，与正常对照组相比，他们的认知功能较低。
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