Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Malaria, Schistosomiasis, and Filariasis, Key Laboratory of Parasitology and Vector Biology of the Chinese Ministry of Health, Shanghai 200025, China.
Chemosphere. 2019 May;222:56-61. doi: 10.1016/j.chemosphere.2019.01.102. Epub 2019 Jan 21.
Schistosomiasis japonica caused by Schistosoma japonicum infection is recognized as a considerable economic and public health concern in Asia. Oncomelania hupensis is the sole intermediate host of S. japonicum. The only molluscicide recommended by World Health Organization (WHO) since 1960s is relative toxic to other aquatic species. In this article, we evaluated the novel molluscicide PPU07 in field trials on their efficiency against O. hupensis and toxicity for local fish. 25% PPU07 sulfate WP exhibited similar molluscicidal effect at 2.0 g/m and 2.0 g/m in the spraying and immersion trials with the WHO recommended molluscicide niclosamide (1 g/m and 1 g/m). The mortality rates reached 95% and 96%, respectively. Moreover, little toxicity was observed for local fish and other aquatic organisms at the effective molluscicidal concentrations. In all, 25% PPU07 sulfate WP is a promising molluscicide for snail control, particularly in semi-commercial or commercial aquaculture ponds.
日本血吸虫病是由日本血吸虫感染引起的，在亚洲被认为是一个相当大的经济和公共卫生问题。钉螺是日本血吸虫唯一的中间宿主。自 20 世纪 60 年代以来，世界卫生组织（WHO）唯一推荐的杀螺剂对其他水生生物相对有毒。在本文中，我们评估了新型杀螺剂 PPU07 在野外试验中的效果，以评估其对钉螺的杀灭效率和对当地鱼类的毒性。25% PPU07 硫酸盐 WP 在喷雾和浸泡试验中，以 2.0 g/m 和 2.0 g/m 的浓度使用时，表现出与 WHO 推荐的杀螺剂氯硝柳胺（1 g/m 和 1 g/m）相似的杀螺效果。死亡率分别达到 95%和 96%。此外，在有效杀螺浓度下，当地鱼类和其他水生生物的毒性很小。总之，25% PPU07 硫酸盐 WP 是一种很有前途的杀螺剂，特别适用于半商业或商业水产养殖池塘。
