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能够无线驱动 473 个电极的 CMOS 刺激芯片,用于皮质视觉假体。

CMOS stimulating chips capable of wirelessly driving 473 electrodes for a cortical vision prosthesis.

机构信息

Department of Electrical and Computer Systems Engineering, Monash University, Clayton, VIC 3800, Australia. Department of Physiology, Monash University, Clayton, VIC 3800, Australia.

出版信息

J Neural Eng. 2019 Apr;16(2):026025. doi: 10.1088/1741-2552/ab021b. Epub 2019 Jan 28.

DOI:10.1088/1741-2552/ab021b
PMID:30690434
Abstract

OBJECTIVE

Implantable neural stimulating and recording devices have the potential to restore capabilities such as vision or motor control to disabled patients, improving quality of life. Implants with a large number of stimulating electrodes typically utilize implanted batteries and/or subcutaneous wiring to deal with their high-power consumption and high data throughput needed to address all electrodes with low latency. The use of batteries places severe limitations on the implant's size, usable duty cycle, device longevity while subcutaneous wiring increases the risk of infection and mechanical damage due to device movement.

APPROACH

To overcome these limitations, we have designed and implemented a system that supports up to 473 implanted stimulating microelectrodes, all wirelessly powered and individually controlled by micropower application specific integrated circuits (ASICs).

MAIN RESULTS

Each ASIC controls 43 electrodes and draws 3.18 mW of power when stimulating through 24 channels. We measured the linearity of the digital-to-analog convertors (DACs) to be 0.21 LSB (integrated non-linearity) and the variability in timing of stimulation pulses across ASICs to be 172 ns.

SIGNIFICANCE

This work demonstrates the feasibility of a new low power ASIC designed to be implanted in the visual cortex of humans. The fully implantable device will greatly reduce the risks of infection and damage due to mechanical issues.

摘要

目的

可植入式神经刺激和记录设备具有为残疾患者恢复视力或运动控制等能力的潜力,从而提高生活质量。具有大量刺激电极的植入物通常利用植入式电池和/或皮下布线来处理其高功耗和高数据吞吐量,以实现所有电极的低延迟。电池的使用对植入物的尺寸、可用占空比、设备寿命施加了严格的限制,而皮下布线则增加了因设备移动而导致感染和机械损坏的风险。

方法

为了克服这些限制,我们设计并实现了一个系统,该系统最多可支持 473 个植入式刺激微电极,所有电极均通过无线方式供电,并由微功耗专用集成电路 (ASIC) 单独控制。

主要结果

每个 ASIC 控制 43 个电极,当通过 24 个通道进行刺激时,消耗 3.18mW 的功率。我们测量了数字到模拟转换器 (DAC) 的线性度为 0.21LSB(集成非线性),以及跨 ASIC 刺激脉冲定时的变化为 172ns。

意义

这项工作证明了一种新的低功耗 ASIC 的可行性,该 ASIC 旨在植入人类的视觉皮层。这种完全可植入的设备将大大降低因机械问题导致的感染和损坏的风险。

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