血管生成素样蛋白在干细胞活性调控中的作用。

Roles of angiopoietin-like proteins in regulation of stem cell activity.

机构信息

Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Japan.

Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, Japan.

出版信息

J Biochem. 2019 Apr 1;165(4):309-315. doi: 10.1093/jb/mvz005.

DOI:10.1093/jb/mvz005

PMID:30690458

Abstract

Various types of stem cells reside in the body and self-renew throughout an organism's lifetime. Such self-renewal is essential for maintenance of tissue homeostasis and is co-ordinately regulated by stem cell-intrinsic signals and signals from stem cell niche. Angiopoietin is a niche-derived signalling molecule well known to contribute to maintenance of haematopoietic stem cells (HSCs). Angiopoietin-like proteins (ANGPTLs) are structurally similar to angiopoietin, and recent studies reveal that they function in angiogenesis, lipid and energy metabolism and regulation of inflammation. However, unlike angiopoietins, activities of ANGPTLs in stem cell maintenance have remained unclear. Recently, several studies have reported an association of ANGPTL signalling with stem cell maintenance. Here, we summarize those findings with a focus on HSCs, intestinal stem cells, neural stem cells and cancer stem cells and discuss mechanisms underlying ANGPTL-mediated stem cell maintenance.

摘要

各种类型的干细胞存在于体内，并在整个生物体的生命周期中自我更新。这种自我更新对于维持组织内稳态是必不可少的，并且受到干细胞固有信号和干细胞龛信号的协调调节。血管生成素是一种已知的龛源性信号分子，有助于维持造血干细胞（HSCs）。血管生成素样蛋白（ANGPTLs）与血管生成素在结构上相似，最近的研究表明它们在血管生成、脂质和能量代谢以及炎症调节中发挥作用。然而，与血管生成素不同，ANGPTLs 在干细胞维持中的活性尚不清楚。最近，有几项研究报告了 ANGPTL 信号与干细胞维持之间的关联。在这里，我们总结了这些发现，重点关注 HSCs、肠干细胞、神经干细胞和癌症干细胞，并讨论了 ANGPTL 介导的干细胞维持的机制。