Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Nephrology Service, Department of Specialties of Internal Medicine, University Hospital of Geneva, Geneva, Switzerland.
J Clin Endocrinol Metab. 2019 Jun 1;104(6):2195-2215. doi: 10.1210/jc.2018-01942.
Sex steroid hormones exhibit anabolic effects whereas a deficiency engenders sarcopenia. Moreover, supraphysiological levels of glucocorticoids promote skeletal muscle atrophy, whereas physiologic levels of glucocorticoids may improve muscle performance.
To study the relationship between both groups of steroid hormones at a physiological range with skeletal muscle mass and function in the general population.
Cross-sectional analysis of the associations between urinary excreted androgens, estrogens, glucocorticoids, and steroid hormone metabolite ratios with lean mass and handgrip strength in a population-based cohort.
Three centers in Switzerland including 1128 participants.
Urinary steroid hormone metabolite excretion by gas chromatography-mass spectrometry, lean mass by bioimpedance analysis, and isometric handgrip strength by dynamometry.
For lean mass a strong positive association was found with 11β-OH-androsterone and with most glucocorticoids. Androsterone showed a positive association in middle-aged and older adults. Estriol showed a positive association only in men. For handgrip strength, strong positive associations with androgens were found in middle-aged and older adults, whereas positive associations were found with cortisol metabolites in young to middle-aged adults.
Sex steroids and glucocorticoids are strongly positively associated with skeletal muscle mass and strength in the upper limbs. The associations with muscle strength appear to be independent of muscle mass. Steroid hormones exert age-specific anabolic effects on lean mass and handgrip strength. Deficits in physical performance of aged muscles may be attenuated by androgens, whereas glucocorticoids in a physiological range increase skeletal muscle mass at all ages, as well as muscle strength in particular in younger adults.
性激素具有合成代谢作用，而缺乏则会导致肌肉减少症。此外，超生理水平的糖皮质激素会促进骨骼肌萎缩，而生理水平的糖皮质激素可能会改善肌肉性能。
研究生理范围内两组类固醇激素与普通人群骨骼肌质量和功能的关系。
对瑞士三个中心的人群进行横断面分析，研究尿中排泄的雄激素、雌激素、糖皮质激素和类固醇激素代谢物比值与瘦体重和握力之间的关系。
瑞士的三个中心，包括 1128 名参与者。
采用气相色谱-质谱法测定尿中类固醇激素代谢产物的排泄，生物电阻抗分析法测定瘦体重，测力计测定等速握力。
对于瘦体重，11β-OH-雄酮和大多数糖皮质激素呈强烈正相关。雄酮在中老年人中呈正相关。雌三醇仅在男性中呈正相关。对于握力，在中老年人中与雄激素呈强烈正相关，而在年轻到中年成年人中与皮质醇代谢物呈正相关。
性激素和糖皮质激素与上肢骨骼肌质量和力量呈强烈正相关。与肌肉力量的相关性似乎独立于肌肉质量。类固醇激素对瘦体重和握力具有年龄特异性的合成代谢作用。年龄较大的肌肉运动功能减退可能被雄激素所缓解，而生理范围内的糖皮质激素则会增加所有年龄段的骨骼肌质量，特别是在年轻成年人中增加肌肉力量。
