Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Ophthalmology, Sahlgrenska University Hospital, Mölndal, Sweden.
Acta Ophthalmol. 2019 Sep;97(6):596-602. doi: 10.1111/aos.14010. Epub 2019 Jan 28.
To examine visual acuity, refraction and ocular status before, during and after hyperbaric oxygen therapy (HBOT).
Twenty-nine patients underwent 40 standard protocol HBOT treatments. In all subjects, refraction and best corrected visual acuity were measured at baseline and after ten, 20, 30 and 40 treatments, and at a 12-week follow-up. A subgroup (n = 19) were given additional examinations at baseline, after 40 treatments and at follow-up including measuring central corneal thickness (CCT), corneal curvature, anterior chamber depth, lens thickness, axial length, fundus morphology, blood pressure and intraocular pressure (IOP). Lens colour and opalescence were graded using the Lens Opacities Classification System III (LOCS III).
Myopic shifts [≥0.5 dioptre (D) spherical equivalent (SE)] occurred in 45 (77.6%) eyes. Median refractive changes of -0.75 D SE (right eye; p < 0.001) and -0.66 D SE (left eye; p < 0.001) were observed between pretreatment and treatment end (Wilcoxon signed rank test). Refraction returned to baseline at follow-up, except for a small persisting change towards myopia, median -0.25 D SE (left eye; p = 0.01). Using the LOCS III, median increases in lens nuclear colour, of 0.6 (right eye; p < 0.001) and 0.7 (left eye; p < 0.001), and opalescence of 0.7 (both eyes; p = 0.01) were found at the last examination. Small reductions were noted in CCT of -6.00 μm (right eye; p = 0.03) and -4.00 μm (left eye; p = 0.03), and IOP of -1.50 mmHg (left eye; p = 0.01).
The transient myopic shift may have been due to lenticular refractive index changes. Reduced lens transparency is a potential consequence of HBOT.
检查高压氧治疗（HBOT）前后的视力、屈光度和眼部状况。
29 名患者接受了 40 次标准方案的 HBOT 治疗。在所有受试者中，在基线和治疗后 10、20、30 和 40 次以及 12 周随访时测量了屈光度和最佳矫正视力。一个亚组（n=19）在基线、40 次治疗后和随访时进行了额外的检查，包括测量中央角膜厚度（CCT）、角膜曲率、前房深度、晶状体厚度、眼轴长度、眼底形态、血压和眼内压（IOP）。使用 Lens Opacities Classification System III (LOCS III) 评估晶状体颜色和混浊程度。
45 只（77.6%）眼出现近视漂移[≥0.5 屈光度（D）等效球镜（SE）]。右眼（p<0.001）和左眼（p<0.001）治疗前后的平均屈光度变化为-0.75 D SE 和-0.66 D SE（Wilcoxon 符号秩检验）。除了向近视方向的小的持续变化外，随访时屈光度恢复到基线，平均为-0.25 D SE（左眼；p=0.01）。使用 LOCS III，右眼（p<0.001）和左眼（p<0.001）晶状体核颜色分别平均增加 0.6 和 0.7，混浊度分别增加 0.7（双眼；p=0.01）。在最后一次检查时发现 CCT 分别减少了-6.00μm（右眼；p=0.03）和-4.00μm（左眼；p=0.03），IOP 减少了-1.50mmHg（左眼；p=0.01）。
短暂性近视漂移可能是由于晶状体折射率的变化。HBOT 的潜在后果是晶状体透明度降低。
