Yoon Hyung-Jun, Seo Eun Hyun, Kim Jae-Jin, Choo Il Han
Department of Neuropsychiatry, Chosun University Hospital, College of Medicine, Chosun University, Gwangju, Korea.
Premedical Science, College of Medicine, Chosun University, Gwangju, Korea.
Clin Psychopharmacol Neurosci. 2019 Feb 28;17(1):12-24. doi: 10.9758/cpn.2019.17.1.12.
Social anxiety disorder (SAD) is associated with aberrant self-referential processing (SRP) such as increased self-focused attention. Aberrant SRP is one of the core features of SAD and is also related to therapeutic interventions. Understanding of the underlying neural correlates of SRP in SAD is important for identifying specific brain regions as treatment targets. We reviewed functional magnetic resonance imaging (fMRI) studies to clarify the neural correlates of SRP and their clinical implications for SAD. Task-based and resting fMRI studies have reported the cortical midline structures including the default mode network, theory of mind-related regions of the temporo-parietal junction and temporal pole, and the insula as significant neural correlates of aberrant SRP in SAD patients. Also, these neural correlates are related to clinical improvement on pharmacological and cognitive-behavioral treatments. Furthermore, these could be candidates for the development of novel SAD treatments. This review supports that neural correlates of SAD may be significant biomarkers for future pathophysiology based treatment.
社交焦虑障碍（SAD）与异常的自我参照加工（SRP）有关，例如自我关注增加。异常的SRP是SAD的核心特征之一，也与治疗干预有关。了解SAD中SRP的潜在神经关联对于确定特定脑区作为治疗靶点很重要。我们回顾了功能磁共振成像（fMRI）研究，以阐明SRP的神经关联及其对SAD的临床意义。基于任务和静息态的fMRI研究报告称，包括默认模式网络、颞顶联合区和颞极的心理理论相关区域以及脑岛在内的皮质中线结构是SAD患者异常SRP的重要神经关联。此外，这些神经关联与药物治疗和认知行为治疗的临床改善有关。此外，这些可能是开发新型SAD治疗方法的候选对象。本综述支持SAD的神经关联可能是未来基于病理生理学治疗的重要生物标志物。
