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三大哮喘表型研究计划:重度哮喘研究计划、哮喘个体化治疗的疾病表型分型,以及用于预测呼吸系统疾病结局的无偏生物标志物。

Three Major Efforts to Phenotype Asthma: Severe Asthma Research Program, Asthma Disease Endotyping for Personalized Therapeutics, and Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome.

机构信息

827 North 21st Street, Philadelphia, PA 19130, USA.

Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

出版信息

Clin Chest Med. 2019 Mar;40(1):13-28. doi: 10.1016/j.ccm.2018.10.016.

DOI:10.1016/j.ccm.2018.10.016
PMID:30691708
Abstract

The SARP, ADEPT, and U-BIOPRED programs are all significant efforts in characterizing asthma and reporting clusters that will assist in designing personalized therapies for asthma, and especially severe asthma. Key aspects of the design of these programs are summarized and major findings are reported in this review.

摘要

SARP、ADEPT 和 U-BIOPRED 项目都是对哮喘进行特征描述和报告聚类的重要努力,这将有助于为哮喘,特别是严重哮喘设计个性化治疗方案。本综述总结了这些项目的设计要点,并报告了主要发现。

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Three Major Efforts to Phenotype Asthma: Severe Asthma Research Program, Asthma Disease Endotyping for Personalized Therapeutics, and Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome.三大哮喘表型研究计划:重度哮喘研究计划、哮喘个体化治疗的疾病表型分型,以及用于预测呼吸系统疾病结局的无偏生物标志物。
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Comparison of Asthma Phenotypes in Severe Asthma Cohorts (SARP, U-BIOPRED, ProAR and COREA) From 4 Continents.来自四大洲的重度哮喘队列(SARP、U-BIOPRED、ProAR和COREA)中哮喘表型的比较。
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