抗生素联合使用：是否应该进行检测？
Antibiotic combinations: should they be tested?
作者信息
Eliopoulos G M, Eliopoulos C T
机构信息
Department of Medicine, New England Deaconess Hospital, Boston, Massachusetts 02215.
出版信息
Clin Microbiol Rev. 1988 Apr;1(2):139-56. doi: 10.1128/CMR.1.2.139.
Abstract
When antibiotic combinations are used to provide a broader spectrum of antimicrobial activity or in an attempt to prevent the emergence of resistant organisms, it is rarely necessary or practical to perform tests of drug interactions in vitro. In vitro testing of combinations may be useful when combinations are used in an attempt to attain synergistic interactions. In some cases, screening methods can be used as substitutes for formal synergy testing. This paper examines the mechanisms of antibiotic interaction leading to synergism or antagonism, surveys attempts to correlate in vitro observations with efficacy in animal models, and reviews clinical data providing evidence for or against a useful role of synergistic antibiotic interactions in the treatment of human infections.
摘要
当联合使用抗生素以提供更广泛的抗菌活性或试图防止耐药菌出现时，很少有必要或实际可行进行体外药物相互作用测试。当联合使用抗生素以试图获得协同相互作用时，体外联合测试可能有用。在某些情况下，筛选方法可作为正式协同测试的替代方法。本文探讨了导致协同或拮抗作用的抗生素相互作用机制，调查了将体外观察结果与动物模型中的疗效相关联的尝试，并综述了支持或反对协同抗生素相互作用在治疗人类感染中发挥有益作用的临床数据。
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