Neuro-innovation Technology and Brain Mapping Laboratory, Federal University of Piauí, Av. São Sebastião, 2819, Bairro São Benedito, Parnaíba, Piauí, CEP: 64202-020, Brazil.
The Northeast Biotechnology Network, Federal University of Piauí, Teresina, Brazil.
Neurol Sci. 2019 Apr;40(4):829-837. doi: 10.1007/s10072-018-3699-1. Epub 2019 Jan 28.
Methylphenidate produces its effects via actions on cortical areas involved with attention and working memory, which have a direct role in time estimation judgment tasks. In particular, the prefrontal and parietal cortex has been the target of several studies to understand the effect of methylphenidate on executive functions and time interval perception. However, it has not yet been studied whether acute administration of methylphenidate influences performance in time estimation task and the changes in alpha band absolute power in the prefrontal and parietal cortex. The current study investigates the influence of the acute use of methylphenidate in both performance and judgment in the time estimation interpretation through the alpha band absolute power activity in the prefrontal and parietal cortex. This is a double-blind, crossover study with a sample of 32 subjects under control (placebo) and experimental (methylphenidate) conditions with absolute alpha band power analysis during a time estimation task. We observed that methylphenidate does not influence task performance (p > 0.05), but it increases the time interval underestimation by over 7 s (p < 0.001) with a concomitant decrease in absolute alpha band power in the ventrolateral prefrontal cortex and dorsolateral prefrontal cortex and parietal cortex (p < 0.001). Acute use of methylphenidate increases the time interval underestimation, consistent with reduced accuracy of the internal clock mechanisms. Furthermore, acute use of methylphenidate influences the absolute alpha band power over the dorsolateral prefrontal cortex, ventrolateral prefrontal cortex, and parietal cortex.
哌醋甲酯通过作用于与注意力和工作记忆相关的皮质区域来产生其效果，而这些区域在时间估计判断任务中起着直接作用。特别是前额叶和顶叶皮层已经成为几项研究的目标，以了解哌醋甲酯对执行功能和时间间隔感知的影响。然而，目前尚未研究急性给予哌醋甲酯是否会影响时间估计任务的表现以及前额叶和顶叶皮层中α波段绝对功率的变化。本研究通过前额叶和顶叶皮层中的α波段绝对功率活动来研究急性使用哌醋甲酯对时间估计解释中的表现和判断的影响。这是一项双盲、交叉研究，样本为 32 名受试者，在对照（安慰剂）和实验（哌醋甲酯）条件下，在进行时间估计任务时进行绝对α波段功率分析。我们观察到哌醋甲酯不会影响任务表现（p>0.05），但它会使时间间隔低估增加超过 7 秒（p<0.001），同时使腹外侧前额叶皮层、背外侧前额叶皮层和顶叶皮层的绝对α波段功率降低（p<0.001）。急性使用哌醋甲酯会增加时间间隔的低估，这与内部时钟机制的准确性降低一致。此外，急性使用哌醋甲酯会影响背外侧前额叶皮层、腹外侧前额叶皮层和顶叶皮层的绝对α波段功率。
