Cheng K Y, Soh Pxy, Bennett P F, Williamson P
Sydney School of Veterinary Science and School of Life and Environmental Sciences, Faculty of Science, Evelyn Williams Building B10, The University of Sydney, New South Wales 2006, Australia.
Aust Vet J. 2019 Jan;97(1-2):14-22. doi: 10.1111/avj.12780.
The aims of this study were to (1) describe the results of a survey on the clinical features of lymphoma in Australian Border Collies and (2) investigate familial clustering of lymphoma-affected dogs by means of pedigree analyses.
Clinical and pedigree information was collected from surveys completed by owners or breeders of Australian Border Collies. Relationships between dogs were derived from pedigree data and kinship was analysed by network and cluster-based algorithms.
A total of 246 respondents completed the survey and 57 lymphoma-affected Australian Border Collies were identified. The mean age of diagnosis was 9.16 (SD ± 3.43) years and the median was 9.7 years (range 2-15 years). The odds of female dogs affected with lymphoma were twice those of males in the reported data (OR = 2.06; 95% CI = 1.13-3.73; P = 0.02). Multicentric, high-grade B-cell lymphoma was the most common form in these dogs. Pedigree analyses identified 21 affected dogs that descended from two sires and 28 cases with a common female ancestor. Average inbreeding between both affected and unaffected dogs was similar (0.16, SD ± 0.06 and 0.15, SD ± 0.06, respectively).
The survey confirmed the presence of a relatively large number of cases of lymphoma in Australian Border Collies, consistent with our previous report of increased risk in this breed. Some dogs were diagnosed at a very young age, but the age ranged over the normal lifespan. Pedigree analyses identified multiple cases within family groups, suggesting a heritable component of the disease in this breed.
本研究的目的是(1)描述一项关于澳大利亚边境牧羊犬淋巴瘤临床特征的调查结果，以及(2)通过系谱分析调查受淋巴瘤影响犬的家族聚集情况。
从澳大利亚边境牧羊犬的主人或饲养者完成的调查中收集临床和系谱信息。犬之间的关系来自系谱数据，并通过基于网络和聚类的算法分析亲缘关系。
共有246名受访者完成了调查，确定了57只受淋巴瘤影响的澳大利亚边境牧羊犬。诊断的平均年龄为9.16(标准差±3.43)岁，中位数为9.7岁(范围2 - 15岁)。在报告的数据中，患淋巴瘤的雌性犬的几率是雄性犬的两倍(OR = 2.06；95%CI = 1.13 - 3.73；P = 0.02)。多中心、高级别B细胞淋巴瘤是这些犬中最常见的形式。系谱分析确定了21只受影响的犬来自两个父系，以及28例有共同母系祖先的病例。受影响和未受影响犬的平均近亲繁殖系数相似(分别为0.16，标准差±0.06和0.15，标准差±0.06)。
该调查证实澳大利亚边境牧羊犬中存在相对大量的淋巴瘤病例，与我们之前关于该品种风险增加的报告一致。一些犬在非常年轻的时候就被诊断出，但年龄范围涵盖了正常寿命。系谱分析确定了家族群体中的多例病例，表明该疾病在这个品种中有遗传成分。
