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[肝平滑肌肉瘤:一例报告]

[Hepatic leiomyosarcoma: a case report].

作者信息

Ter-Ovanesov M D, Valkin D L, Gaboyan A S, Kukosh M Yu, Ronzin A V, Andrianova V S, Larin A L, Zhuk A I

出版信息

Vopr Onkol. 2016;62(6):857-862.

Abstract

The authors present a review of pathogenesis, diagnosis and various approaches to treatment for an extremely rare tumor - primary hepatic leiomyosarcoma. This tumor is dif- ficult to be diagnosed by imaging examinations. The prevalent method of treatment is a radical resection (RO surgery). Ac- cording to literature the median survival of patients with LMSL is about one year with DFS after treatment about 10 months. Also the authors describe a case report of the successful cure of middle-aged female with primary hepatic leiomyosarcoma and Hodgkin's lymphoma in the anamnesis. She has undergone 6 cycles of neoadjuvant chemotherapy with Ifosfamide and Doxorubicin. The tumour response was estimated as partial. Then patient has undergone radical surgery in the volume of extended left hemihepatectomy with LND. Follow-up exami- nation 38 months after treatment revealed no progression of the disease.

摘要

作者对一种极其罕见的肿瘤——原发性肝平滑肌肉瘤的发病机制、诊断及各种治疗方法进行了综述。这种肿瘤很难通过影像学检查确诊。普遍的治疗方法是根治性切除(RO手术)。根据文献,原发性肝平滑肌肉瘤患者的中位生存期约为1年,治疗后的无病生存期约为10个月。作者还描述了一例病史中患有原发性肝平滑肌肉瘤和霍奇金淋巴瘤的中年女性成功治愈的病例报告。她接受了6个周期的异环磷酰胺和阿霉素新辅助化疗。肿瘤反应评估为部分缓解。然后患者接受了扩大左半肝切除加淋巴结清扫的根治性手术。治疗后38个月的随访检查显示疾病无进展。

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