Adler L T, Adler F L
Immunol Commun. 1978;7(3):269-80. doi: 10.3109/08820137809025472.
The mechanism of allotype suppression in rabbits has been investigated by studying the in vitro immune responses of spleen cells from rabbits in advanced stages of spontaneous recovery from suppression. Whereas the spleen cells from highly suppressed rabbits can be released from their suppressed state only if treated with a combination of antibodies against the non-suppressed type and immunoglobulin (Ig) of the suppressed type, treatment with either of these two components alone suffices to overcome suppression when cells of more poorly suppressed spleen donors are used. The demonstration that suppression can be abrogated by normal Ig of the suppressed type alone, when cells are obtained from rabbits in the final phases of suppression, lends further support to the previously suggested concept that the probable role of this normal Ig in the release phenomenon may be that of neutralizing an effector of allotype-specific repression, possibly involving suppressor cells.
通过研究处于自发恢复抑制晚期的兔子脾脏细胞的体外免疫反应，对兔子同种异型抑制机制进行了研究。高度抑制的兔子的脾脏细胞，只有在用针对非抑制型抗体和抑制型免疫球蛋白（Ig）的组合处理时，才能从其抑制状态中释放出来。然而，当使用抑制程度较轻的脾脏供体的细胞时，单独使用这两种成分中的任何一种进行处理就足以克服抑制。当从处于抑制末期的兔子获得细胞时，仅用抑制型的正常Ig就能消除抑制，这一证明进一步支持了先前提出的概念，即这种正常Ig在释放现象中的可能作用可能是中和同种异型特异性抑制的效应器，可能涉及抑制细胞。
