Lee S K, Dresser D W
Immunology. 1981 Apr;42(4):601-10.
In an adoptive transfer assay it has been shown that a form of allotype suppression can be induced in adult spleen cells. Use of SPF congenic mice, and either anti-allotype serum freed of IgM rheumatoid factor or affinity prepared antibody, has helped to eliminate the possibility of a role for non-specific factors in allotype suppression. Both memory-cell development and a conventional primary response are more susceptible to suppression than memory expression in a secondary response. Non-specific suppressive effects on isotypes other than that of the target allotype (CH) are present but are much smaller than for specific suppression.
在过继转移试验中已表明，可在成年脾细胞中诱导出一种同种异型抑制形式。使用无IgM类风湿因子的抗同种异型血清或亲和制备抗体的SPF同基因小鼠，有助于消除非特异性因子在同种异型抑制中起作用的可能性。与二次应答中的记忆表达相比，记忆细胞发育和传统的初次应答更容易受到抑制。对除靶同种异型（CH）之外的同种型存在非特异性抑制作用，但比特异性抑制作用小得多。
