Federal University of Pelotas, Post-Graduate Program in Epidemiology, Pelotas 96020-220, Brazil.
Federal University of Rio Grande do Sul, Department of Genetics, Porto Alegre 915010-970, Brazil.
Genes (Basel). 2019 Jan 28;10(2):88. doi: 10.3390/genes10020088.
Circadian and sleep disorders, short sleep duration, and evening chronotype are often present in attention-deficit/hyperactivity disorder (ADHD). , considered the master gene in the circadian rhythm, has been explored by few studies. Understanding the relationship between ADHD and may provide additional information to understand the correlation between ADHD and sleep problems. In this study, we aimed to explore the association between ADHD and , using several genetic markers to comprehensively cover the gene extension. A total of 259 ADHD children and their parents from a Brazilian clinical sample were genotyped for eight single nucleotide polymorphisms (SNPs) in the locus. We tested the individual markers and the haplotype effects using binary logistic regression. Binary logistic and linear regressions considering ADHD symptoms among ADHD cases were conducted as secondary analysis. As main result, the analysis showed a risk effect of the G-A-T-G-G-C-G-A (rs534654, rs1801260, rs6855837, rs34897046, rs11931061, rs3817444, rs4864548, rs726967) haplotype on ADHD. A suggestive association between ADHD and rs534654 was observed. The results suggest that the genetic susceptibility to circadian rhythm attributed to the gene may play an important role on ADHD.
昼夜节律和睡眠障碍、睡眠时间短、夜间时型通常存在于注意力缺陷/多动障碍 (ADHD) 中。 被认为是昼夜节律的主基因，很少有研究探索过它。了解 ADHD 与 之间的关系可能会提供更多信息，以了解 ADHD 与睡眠问题之间的相关性。在这项研究中，我们旨在探索 ADHD 与 之间的关联，使用几个遗传标记来全面涵盖基因延伸。总共对来自巴西临床样本的 259 名 ADHD 儿童及其父母进行了 基因座的 8 个单核苷酸多态性 (SNP) 的基因分型。我们使用二元逻辑回归测试了个体标记和单倍型效应。对 ADHD 病例中的 ADHD 症状进行了二进制逻辑和线性回归的二次分析。主要结果表明，G-A-T-G-G-C-G-A (rs534654、rs1801260、rs6855837、rs34897046、rs11931061、rs3817444、rs4864548、rs726967) 单倍型对 ADHD 有风险效应。观察到 rs534654 与 ADHD 之间存在关联的迹象。结果表明，归因于 基因的昼夜节律遗传易感性可能在 ADHD 中发挥重要作用。
