Department of Psychiatry, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, South Korea.
Mind-Neuromodulation Laboratory, Hallym University College of Medicine, Chuncheon, South Korea.
Int Psychogeriatr. 2019 Aug;31(8):1151-1158. doi: 10.1017/S1041610218001527.
Despite the possibility that cognitive deficits associated with depression may have different patterns depending on the level of neurocognitive impairment, there remains no clear evidence of this. This study aimed to investigate the differential association between depression and cognitive function in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD).
A cross-sectional analysis was performed of data from 1,724 patients with MCI and 1,247 patients with AD from the Clinical Research Center for Dementia in Korea. Depression was assessed using the Korean form of the Geriatric Depression Scale, and cognition was measured using the Seoul Neuropsychological Screening Battery, which includes five domains (attention, language and related function, visuospatial function, memory, and frontal/executive function).
Significant differences were found between the two groups (non-depressed vs. depressed) in visuospatial, memory, and executive function domains in the MCI group, as well as in the attention domain in the AD group. The association between depressive symptoms and cognitive function was significantly greater in patients with MCI than in those with AD. These associations were more pronounced in memory and executive function.
Our findings suggest that the association between depression and decreased cognitive function is more pronounced in MCI than AD.
尽管与抑郁相关的认知缺陷可能因神经认知损伤的程度不同而呈现出不同的模式，但目前尚无明确证据表明这一点。本研究旨在探讨轻度认知障碍（MCI）和阿尔茨海默病（AD）患者中抑郁与认知功能之间的差异关联。
对来自韩国临床痴呆研究中心的 1724 名 MCI 患者和 1247 名 AD 患者的数据进行了横断面分析。使用老年抑郁量表的韩国版评估抑郁，使用首尔神经心理筛选测验（包括注意力、语言和相关功能、视空间功能、记忆和额叶/执行功能五个领域）来测量认知。
在 MCI 组中，非抑郁组与抑郁组在视空间、记忆和执行功能领域存在显著差异，在 AD 组中，在注意力领域也存在显著差异。在 MCI 患者中，抑郁症状与认知功能之间的关联明显大于 AD 患者。这些关联在记忆和执行功能方面更为明显。
我们的研究结果表明，抑郁与认知功能下降之间的关联在 MCI 中比在 AD 中更为显著。
