Turk J Med Sci. 2015;45(5):1137-40. doi: 10.3906/sag-1404-179.
BACKGROUND/AIM: Mild cognitive impairment (MCI) is defined as a pathological stage between 'healthy aging' and 'dementia' In this study, cases of MCI were compared with early-stage Alzheimer disease (AD) and age-related cognitive decline (ARCD) in terms of cognitive profiles in order to find a connection between MCI and AD.
Patients who were comparable in terms of age and sex and who met the criteria of MCI, ARCD, or early-stage AD were included in the study retrospectively. Wechsler memory scale, executive function, visuospatial, language, and memory tests were applied to all subjects. Additionally, all patients completed a mini-mental state examination test, geriatric depression scale, and activities of daily living scale.
Complex attention tests and long-term memory tests were more impaired in MCI patients when compared with ARCD. However, there were no significant differences between the MCI and ARCD cases in activities of daily living. Memory and executive functions were more deteriorated in patients with AD in comparison to MCI.
During the follow-up period of ARCD, impairment in orientation, complex attention, and long-term memory should suggest the diagnosis of MCI. When personal information and executive functions are affected in MCI, AD should be carefully considered.
背景/目的：轻度认知障碍 (MCI) 被定义为“健康衰老”和“痴呆”之间的病理阶段。在这项研究中，我们比较了 MCI 病例与早期阿尔茨海默病 (AD) 和与年龄相关的认知衰退 (ARCD) 的认知特征，以寻找 MCI 与 AD 之间的联系。
回顾性纳入年龄和性别相匹配且符合 MCI、ARCD 或早期 AD 标准的患者。我们对所有受试者进行了韦氏记忆量表、执行功能、视空间、语言和记忆测试。此外，所有患者均完成了简易精神状态检查、老年抑郁量表和日常生活活动量表。
与 ARCD 相比，MCI 患者的复杂注意力测试和长期记忆测试受损更严重。然而，MCI 和 ARCD 患者在日常生活活动方面无显著差异。与 MCI 相比，AD 患者的记忆和执行功能更差。
在 ARCD 的随访期间，定向、复杂注意力和长期记忆的损伤应提示 MCI 的诊断。当 MCI 患者的个人信息和执行功能受到影响时，应仔细考虑 AD。
