Yuan Jinping, Sun Chong, Jiang Shibin, Lu Yansong, Zhang Yuhui, Gao Xing-Hua, Wu Yan, Chen Hong-Duo
Key Lab of Immunodermatology, Ministry of Health, Department of Dermatology, The First Hospital of China Medical University, Shenyang, China.
Front Endocrinol (Lausanne). 2019 Jan 15;9:803. doi: 10.3389/fendo.2018.00803. eCollection 2018.
Associations between vitiligo and thyroid disorders have been suggested, However, the prevalence of thyroid disorders in vitiligo vary widely. To conduct a systematic review and meta-analysis assessing the prevalence of thyroid disorders in patients with vitiligo. The PubMed, Cochrane Library, EMBASE, CNKI (China National Knowledge Infrastructure), Chongqing VIP database, and Wanfang database from inception to August 2, 2018 were systematically searched. The pooled prevalence and its 95% confidence interval (CI) were calculated. A total of 77 eligible studies were identified and included, published from 1968 to 2018. Six thyroid disorders including subclinical hyperthyroidism, overt hyperthyroidism, subclinical hypothyroidism, overt hypothyroidism, Graves disease, and Hashimoto thyroiditis were described. The numbers of relative studies were 54 in overt hypothyroidism, 50 in overt hyperthyroidism, 25 in subclinical hypothyroidism, 19 in Hashimoto thyroiditis, 16 in Graves disease, and 10 in subclinical hyperthyroidism. The highest prevalence was 0.06 (95% CI: 0.04-0.07) in subclinical hypothyroidism, and the lowest was 0.01 in subclinical hyperthyroidism (95% CI: 0.00-0.01) or Graves disease (95% CI: 0.01-0.02). Six thyroid disorders showed various prevalence in vitiligo. The highest prevalence was in subclinical hypothyroidism, and the lowest was in subclinical hyperthyroidism or Graves disease. Screening vitiligo patients for thyroid disorders seem plausible, in an effort to detect potential thyroid diseases or to assess the risk of future onset.
白癜风与甲状腺疾病之间的关联已被提出，然而，白癜风患者中甲状腺疾病的患病率差异很大。为了进行一项系统评价和荟萃分析，评估白癜风患者中甲状腺疾病的患病率。系统检索了从创刊至2018年8月2日的PubMed、Cochrane图书馆、EMBASE、中国知网（中国国家知识基础设施）、重庆维普数据库和万方数据库。计算合并患病率及其95%置信区间（CI）。共纳入77项符合条件的研究，发表时间为1968年至2018年。描述了六种甲状腺疾病，包括亚临床甲状腺功能亢进、显性甲状腺功能亢进、亚临床甲状腺功能减退、显性甲状腺功能减退、格雷夫斯病和桥本甲状腺炎。显性甲状腺功能减退的相关研究有54项，显性甲状腺功能亢进的相关研究有50项，亚临床甲状腺功能减退的相关研究有25项，桥本甲状腺炎的相关研究有19项，格雷夫斯病的相关研究有16项，亚临床甲状腺功能亢进的相关研究有10项。亚临床甲状腺功能减退的患病率最高，为0.06（95%CI：0.04 - 0.07），亚临床甲状腺功能亢进（95%CI：0.00 - 0.01）或格雷夫斯病（95%CI：0.01 - 0.02）的患病率最低，为0.01。六种甲状腺疾病在白癜风患者中的患病率各不相同。患病率最高的是亚临床甲状腺功能减退，最低的是亚临床甲状腺功能亢进或格雷夫斯病。对白癜风患者进行甲状腺疾病筛查似乎是合理的，以便检测潜在的甲状腺疾病或评估未来发病的风险。
