Oguz Topal Ilteris, Duman Hatice, Gungor Sule, Kocaturk Emek, Kuteyla Can Pelin
Ilteris Oguz Topal, MD, Department of Dermatology, Okmeydani Training and Research Hospital, Istanbul, Turkey;
Acta Dermatovenerol Croat. 2016 Jun;24(2):124-9.
Vitiligo is an acquired, pigmentary skin disorder that affects about 0.1-4.0% of the population. In this study, we aimed to investigate the disease features such as age of onset, disease duration, clinical and sociodemographic characteristics, and laboratory parameters of patients with vitiligo. A hundred patients who were in follow-up for vitiligo between the period of June 2013 and May 2014 were included in the study. The clinical features and laboratory parameters were retrospectively obtained from the records of the patients. The mean age was 34.9±16.8 years. The most common clinical types were focal and acrofacial. Facial involvement was the most common localization. Forty-five (45%) patients had an associated systemic disease. Autoimmune thyroid disease, essential hypertension, and alopecia areata, which were observed in 28%, 8%, and 5% of patients, respectively, were the most common associated diseases. Twenty-one percent of the patients had low ferritin levels, 20% had low iron levels, 12% had low vitamin B12 levels, and 1% had low folic acid levels. The prevalence of anti-TG (anti-thyroglobulin) and anti-TPO (anti-thyroid peroxidase) antibodies were found 17% and 27% of the patients, respectively. We found that the clinical characteristics of vitiligo in our patients were similar to those in other studies. We observed laboratory abnormalities and accompanying diseases associated with vitiligo. Therefore we conclude that laboratory examinations including thyroid antibodies and regular follow-up of these patients are essential.
白癜风是一种后天性色素性皮肤病,影响约0.1%-4.0%的人群。在本研究中,我们旨在调查白癜风患者的发病年龄、病程、临床和社会人口学特征以及实验室参数等疾病特征。本研究纳入了2013年6月至2014年5月期间接受白癜风随访的100例患者。临床特征和实验室参数是从患者记录中回顾性获取的。平均年龄为34.9±16.8岁。最常见的临床类型是局限性和肢端面部型。面部受累是最常见的部位。45例(45%)患者伴有全身性疾病。自身免疫性甲状腺疾病、原发性高血压和斑秃分别在28%、8%和5%的患者中观察到,是最常见的伴发疾病。21%的患者铁蛋白水平低,20%的患者铁水平低,12%的患者维生素B12水平低,1%的患者叶酸水平低。抗TG(抗甲状腺球蛋白)和抗TPO(抗甲状腺过氧化物酶)抗体的患病率分别在17%和27%的患者中发现。我们发现我们患者中白癜风的临床特征与其他研究中的相似。我们观察到与白癜风相关的实验室异常和伴发疾病。因此我们得出结论,包括甲状腺抗体在内的实验室检查以及对这些患者的定期随访至关重要。