Bhowmik Sourav, Chakrabarti Indranil, Ghosh Piyali, Bera Pranati, Banik Tarak
Dept. of Pathology, Ruby General Hospital, Kolkata, India.
Dept of Pathology, North Bengal Medical College, The West Bengal University Of Health Sciences, Siliguri, Darjeeling, India.
Iran J Pathol. 2018 Spring;13(2):179-187. Epub 2018 Jul 17.
BACKGROUND & OBJECTIVE: Fine needle aspiration cytology (FNAC) is an easy, rapid, and less hazardous tool to diagnose the intra-abdominal lesions with various imaging modalities adding to its sensitivity and accuracy. However, sometimes it does not yield adequate information for precise diagnosis and the risk of false-negative and indeterminate diagnosis is always present. Cellblock preparations may be particularly helpful in such problematic cases. The current study aimed atevaluating and comparing the cytological as well as histopathological features of different intra-abdominal mass lesions.
Image-guided FNAC followed by cell block were performed on 167 patients from June 2012 to May 2013. Histologically correlated 111 cases were evaluated. Results of conventional smear, cell block, and combination of FNAC with cell block were compared with histopathological findings regarding diagnostic sensitivity, specificity, and accuracy of diagnosis.
Cell block was more specific to diagnose these lesions than FNAC (95.49% versus 90.09%). Combined application of cell block with FNAC was more specific (96.39%) than cell block alone with 100% diagnostic accuracy.
Application of a combination of cell block with FNAC was more useful to diagnose intra-abdominal mass lesions.
细针穿刺细胞学检查（FNAC）是一种简便、快速且风险较低的诊断腹腔内病变的方法，多种成像方式可提高其敏感性和准确性。然而，有时它无法提供足够信息用于精确诊断，假阴性和诊断不明确的风险始终存在。细胞块制备在这类疑难病例中可能特别有用。本研究旨在评估和比较不同腹腔内肿块病变的细胞学及组织病理学特征。
2012年6月至2013年5月，对167例患者进行了影像引导下的FNAC及随后的细胞块制备。对111例组织学相关病例进行了评估。将传统涂片、细胞块以及FNAC与细胞块联合应用的结果在诊断敏感性、特异性和诊断准确性方面与组织病理学结果进行比较。
细胞块诊断这些病变比FNAC更具特异性（95.49%对90.09%）。细胞块与FNAC联合应用比单独使用细胞块更具特异性（96.39%），诊断准确性达100%。
细胞块与FNAC联合应用对诊断腹腔内肿块病变更有用。
