Zare-Mirzaie Ali, Kazeminezhad Behrang, Akbari Ghouchani Mona
Dept of Pathology, Iran University of Medical Sciences, Rassool Akram Hospital, Tehran, Iran.
Dept of Pathology, Shahid Beheshti University of Medical Science, Shahid Modarres Hospital, Tehran, Iran.
Iran J Pathol. 2018 Spring;13(2):212-219. Epub 2018 Jul 17.
BACKGROUND & OBJECTIVE: Increase in intraand extracellular glucose levels can cause oxidative stress, and theprolonged imbalance between prooxidants and antioxidantscan lead to cell damage and the associated complications in patients with diabetes. Vitamin D acts as a strong antioxidant in the body and several studies emphasized on its important role to preventoxidative stress in prediabeticand diabetic subjects. The current study aimed at determining and comparingthe total antioxidant capacity (TAC) in individuals with hemoglobin A1c(HbA1c) below and above 6.5%, and its correlation with vitamin D levels.
The current cross sectional study was conducted on a total of 107patients with diabetes (HbA1c >6.5%) and 107 non-diabetic subjects (HbA1c<6.5%)referred toRassoolAkram Hospital, Tehran, Iranfrom2015 to 2016, as the sample population. The two groups were compared regarding their TAC and vitamin D serum levels and the association between vitamin D concentration and TAC was evaluated.
Age and body mass index (BMI)were significantly higher in patients with diabetes,comparedwiththe serum levels of vitamin D and TAC (P<0.001 for both). Both TAC and vitamin D levels were significantly lower in the group with diabetesand a weak significant correlation was observedbetween the two factors (r=0.2, =0.003). In multivariate regression model, the duration of diabetes was also significantly associated with TAC level (beta coefficient=-0.82, <0.001).
The low serum levels of TAC and vitamin D in patients with diabetescould be indicative of oxidative stress in the presence of high blood glucose levels. Supplementation of vitamin D in patients with diabetes might be effective to control thenegative impacts of the disease and decreasecells' exposure to oxidative environment in prediabetes.
细胞内和细胞外葡萄糖水平升高可导致氧化应激，而促氧化剂和抗氧化剂之间长期失衡会导致糖尿病患者细胞损伤及相关并发症。维生素D在体内发挥强大的抗氧化剂作用，多项研究强调了其在预防糖尿病前期和糖尿病患者氧化应激方面的重要作用。本研究旨在测定和比较糖化血红蛋白（HbA1c）低于和高于6.5%的个体的总抗氧化能力（TAC），及其与维生素D水平的相关性。
本横断面研究共纳入2015年至2016年转诊至伊朗德黑兰拉苏勒·阿克拉姆医院的107例糖尿病患者（HbA1c>6.5%）和107例非糖尿病受试者（HbA1c<6.5%）作为样本群体。比较两组的TAC和维生素D血清水平，并评估维生素D浓度与TAC之间的关联。
糖尿病患者的年龄和体重指数（BMI）显著高于非糖尿病患者，而维生素D和TAC的血清水平则显著低于非糖尿病患者（两者P<0.001）。糖尿病组的TAC和维生素D水平均显著较低，且观察到这两个因素之间存在弱显著相关性（r=0.2，P=0.003）。在多变量回归模型中，糖尿病病程也与TAC水平显著相关（β系数=-0.82，P<0.001）。
糖尿病患者血清TAC和维生素D水平较低可能表明在高血糖水平下存在氧化应激。糖尿病患者补充维生素D可能有效控制疾病的负面影响，并减少糖尿病前期细胞暴露于氧化环境。
