Departments of Gynaecology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Departments of Intensive Care Unit, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
BMC Womens Health. 2020 Apr 6;20(1):69. doi: 10.1186/s12905-020-00930-w.
Vitamin E, which is critically important in the whole process of reproduction, can antagonize the oxidative stress caused by the oxygen free radicals and antioxidant imbalance and regulate normal physiological function of the reproductive system. The effect of short-term supplementation of vitamin E on outcomes of infertile women with polycystic ovary syndrome (PCOS) when they underwent ovulation induction with clomiphene citrate (CC) and human menopausal gonadotropin (HMG) remains unknown.
This was a retrospective cohort clinical trial from October 2015 to April 2017. A total of 321 PCOS cases underwent ovulation induction with CC and HMG. Patients in group A (n = 110) did not receive vitamin E while patients in group B (n = 105) and group C (n = 106) received oral treatment of vitamin E at 100 mg/day during follicular phase and luteal phase, respectively.
It was observed no significant differences of ovulation rate, clinical pregnancy rate, and ongoing pregnancy rate among the three groups. It was interesting that dosage of HMG were significant lower in group B compared with those in group A and group C (P<0.05).
A short-term supplementation of vitamin E can improve oxidative stress, and reduce exogenous HMG dosage to lower the economic cost with a similar pregnancy rate in the ovulation induction cycle. However, the supplementation does not alter the pregnancy rate in the ovulation induction cycle.
ChiCTR-OOC-14005389, 2014.
维生素 E 在生殖过程的各个环节都起着至关重要的作用，它可以拮抗氧自由基引起的氧化应激和抗氧化失衡，调节生殖系统的正常生理功能。对于接受枸橼酸氯米酚（CC）和人绝经期促性腺激素（HMG）促排卵的多囊卵巢综合征（PCOS）不孕妇女，短期补充维生素 E 对结局的影响尚不清楚。
这是一项 2015 年 10 月至 2017 年 4 月的回顾性队列临床试验。共有 321 例 PCOS 患者接受 CC 和 HMG 促排卵。A 组（n=110）患者未接受维生素 E 治疗，B 组（n=105）和 C 组（n=106）患者在卵泡期和黄体期分别接受 100mg/天的口服维生素 E 治疗。
三组的排卵率、临床妊娠率和持续妊娠率均无显著差异。有趣的是，B 组的 HMG 用量明显低于 A 组和 C 组（P<0.05）。
短期补充维生素 E 可以改善氧化应激，减少外源性 HMG 用量，降低经济成本，同时不影响排卵诱导周期的妊娠率。
ChiCTR-OOC-14005389，2014。
