Investigating the causal relationship between neuroticism and depression via Mendelian randomization.
作者信息
Speed D, Hemani G, Speed M S, Børglum A D, Østergaard S D
机构信息
Aarhus Institute for Advanced Studies, Aarhus University, Aarhus, Denmark.
UCL Genetics Institute, University College London, London, UK.
出版信息
Acta Psychiatr Scand. 2019 Apr;139(4):395-397. doi: 10.1111/acps.13009. Epub 2019 Feb 17.
Abstract
摘要
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Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.对 449484 个人的神经质进行全基因组关联研究的荟萃分析确定了新的遗传位点和途径。
Nat Genet. 2018 Jul;50(7):920-927. doi: 10.1038/s41588-018-0151-7. Epub 2018 Jun 25.
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The MR-Base platform supports systematic causal inference across the human phenome.MR-Base 平台支持在人类表型全范围内进行系统因果推断。
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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.全基因组关联分析确定了 44 个风险变异，并完善了重度抑郁症的遗传结构。
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