石松生物碱：石松定 A，来自石松属植物的一种罕见石松堿-哌啶加合物，以及石松兰定 D 和石杉堿 H 的绝对构型。
Lycopodium Alkaloids: Lycoplatyrine A, an Unusual Lycodine-Piperidine Adduct from Lycopodium platyrhizoma and the Absolute Configurations of Lycoplanine D and Lycogladine H.
机构信息
Department of Chemistry, Faculty of Science , University of Malaya , 50603 Kuala Lumpur , Malaysia.
School of Pharmacy , University of Nottingham Malaysia Campus , Jalan Broga , 43500 Semenyih , Selangor , Malaysia.
出版信息
J Nat Prod. 2019 Feb 22;82(2):324-329. doi: 10.1021/acs.jnatprod.8b00754. Epub 2019 Jan 30.
Three new Lycopodium alkaloids comprising two lycodine-type alkaloids (1, 2) and one fawcettimine alkaloid (3), in addition to 16 known alkaloids, were isolated from Lycopodium platyrhizoma. The structures of these alkaloids were elucidated based on analysis of their NMR and MS data. Lycoplatyrine A (1) represents an unusual lycodine-piperidine adduct. The structures and absolute configurations of lycoplanine D (hydroxy-des- N-methyl-α-obscurine, 10) and lycogladine H (11) were confirmed by X-ray diffraction analysis.
从土生土长的石松中分离得到 3 种新的石松生物碱，包括 2 种石松堿型生物碱（1、2）和 1 种法氏石松堿（3），此外还分离得到 16 种已知生物碱。根据 NMR 和 MS 数据分析，这些生物碱的结构得到了阐明。石松拉亭 A（1）代表了一种不寻常的石松-哌啶加合物。通过 X 射线衍射分析确定了石松林定 D（羟基-去 N-甲基-α- obscurine，10）和石松吉定 H（11）的结构和绝对构型。
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