大学生和教师中的认知与情绪障碍：使用雷卡南（胞磷胆碱）进行治疗的可能性
[Cognitive and emotional disorders in university students and teachers: the possibility of treatment with recognan (citicoline)].
作者信息
Nemkova S A, Semenov D V, Petrova E A, Savchenko D V, Zavadenko N N, Vozvyshaeva M Yu, Kanishcheva A S, Ralleva A V, Logvinova E M, Tsvetkov D A, Charikova E V, Romanenko N I, Zagaryan D A, Boldyrev V G
机构信息
Pirogov Russian National Research Medical University, Moscow, Russia.
Russian State Social Unoversity, Moscow, Russia.
出版信息
Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(12):11-18. doi: 10.17116/jnevro201811812111.
AIM
To study the efficacy of recognan (citicoline) in treatment of cognitive, emotional, autonomic, asthenic disorders in university students and teachers.
MATERIAL AND METHODS
Fifty-eight subjects (17 men and 41 women), mean age 27.75±12.05 years, including who 42 students and 16 teachers were studied. The sample was randomized into 2 groups (29 each): the main sub-group received oral therapy with recognan for 30 days, while the daily dosage was 500 mg (5 ml). In the control group, no drug therapy was performed. Patient's state was assessed with a large battery of psychological tests and psychometric scales. The follow-up period was 30 days. All participants were examined three times (initially, in the middle of the study (day 15), in the end of the study (day 30)).
RESULTS AND CONCLUSION
Asthenic state was detected in 69%, autonomic dysfunction in 82.7%, sleep disorders in 75.8% of subjects. A high level of state anxiety was revealed in 22.2%, trait anxiety in 29.8%, a high level of stress was determined in 6,9%. It is shown that the use of recognan (citicoline) has a positive effect on compensation of autonomic and asthenic disorders, improves cognitive status, corrects psycho-emotional disorders, when used as a short (2 week) and month course.
目的
研究胞磷胆碱钠在治疗大学生和教师的认知、情绪、自主神经及虚弱性障碍方面的疗效。
材料与方法
对58名受试者（17名男性和41名女性）进行研究，平均年龄27.75±12.05岁，其中包括42名学生和16名教师。将样本随机分为2组（每组29人）：主要亚组接受胞磷胆碱钠口服治疗30天，每日剂量为500毫克（5毫升）。对照组未进行药物治疗。通过一系列心理测试和心理测量量表评估患者状态。随访期为30天。所有参与者接受三次检查（最初、研究中期（第15天）、研究结束时（第30天））。
结果与结论
69% 的受试者存在虚弱状态，82.7% 存在自主神经功能障碍，75.8% 存在睡眠障碍。22.2% 的受试者存在高水平的状态焦虑，29.8% 存在特质焦虑，6.9% 存在高水平的压力。结果表明，胞磷胆碱钠在短期（2周）和一个月疗程使用时，对自主神经和虚弱性障碍的代偿有积极作用，可改善认知状态，纠正心理情绪障碍。
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