烟酰胺在光保护和皮肤癌化学预防中的作用：疗效和安全性综述。

Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety.

机构信息

Discipline of Dermatology, Bosch Institute, University of Sydney and Royal Prince Alfred Hospital Sydney, Sydney, NSW, Australia.

Melanoma Institute Australia, Sydney, NSW, Australia.

出版信息

Exp Dermatol. 2019 Feb;28 Suppl 1:15-22. doi: 10.1111/exd.13819.

DOI:10.1111/exd.13819

PMID:30698874

Abstract

Nicotinamide is a water-soluble vitamin B3 derivative that has many roles in medicine. This review examines the role of nicotinamide in dermatology and its actions in preventing photoageing and skin cancers in humans. Nicotinamide prevents ultraviolet radiation (UV) from reducing ATP levels and inhibiting glycolysis, thus preventing the UV radiation-induced energy crisis. This enhances DNA repair and reduces UV-induced suppression of immunity. Randomised controlled clinical trials have also shown that nicotinamide reduces transepidermal water loss and the development of new non-melanoma skin cancers in high-risk humans. This review also examines nicotinamide's safety profile.

摘要

烟酰胺是一种水溶性维生素 B3 衍生物，在医学中有多种作用。这篇综述考察了烟酰胺在皮肤科中的作用及其在预防人类光老化和皮肤癌方面的作用。烟酰胺可防止紫外线 (UV) 降低 ATP 水平并抑制糖酵解，从而防止 UV 辐射引起的能量危机。这增强了 DNA 修复并减少了 UV 诱导的免疫抑制。随机对照临床试验还表明，烟酰胺可减少高危人群的经表皮水分流失和新发非黑素瘤性皮肤癌的发展。本文还考察了烟酰胺的安全性概况。