Chen Andrew C, Damian Diona L
Discipline of Dermatology, Bosch Institute, Central Clinical School, University of Sydney, Sydney, New South Wales, Australia; Department of Dermatology, Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Australas J Dermatol. 2014 Aug;55(3):169-75. doi: 10.1111/ajd.12163. Epub 2014 Mar 17.
Nicotinamide, an amide form of vitamin B3, boosts cellular energy and regulates poly-ADP-ribose-polymerase 1, an enzyme with important roles in DNA repair and the expression of inflammatory cytokines. Nicotinamide shows promise for the treatment of a wide range of dermatological conditions, including autoimmune blistering disorders, acne, rosacea, ageing skin and atopic dermatitis. In particular, recent studies have also shown it to be a potential agent for reducing actinic keratoses and preventing skin cancers.
烟酰胺是维生素B3的一种酰胺形式，可增强细胞能量并调节聚ADP核糖聚合酶1，该酶在DNA修复和炎性细胞因子表达中起重要作用。烟酰胺在治疗多种皮肤病方面显示出前景，包括自身免疫性水疱病、痤疮、玫瑰痤疮、皮肤老化和特应性皮炎。特别是，最近的研究还表明它是一种减少光化性角化病和预防皮肤癌的潜在药物。
