MRC Laboratory for Molecular Cell Biology, University College London, London, United Kingdom.
PLoS Biol. 2019 Jan 30;17(1):e3000124. doi: 10.1371/journal.pbio.3000124. eCollection 2019 Jan.
The eradication of smallpox is one of the greatest medical successes in history. Vaccinia virus was made famous by being the virus used in the live vaccine that enabled this feat. Nearly 40 years on from that success, this prototypical poxvirus continues to empower the exploration of fundamental biology and the potential to develop therapeutics against some of the major causes of death and disease in the modern world.
根除天花是医学史上最伟大的成就之一。牛痘病毒因被用于实现这一壮举的活疫苗而声名远扬。在这一成功近 40 年后，这种典型的痘病毒继续为探索基础生物学提供支持，并有可能针对现代世界一些主要死亡和疾病原因开发疗法。
