Neurology Department, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
PLoS One. 2019 Jan 30;14(1):e0211513. doi: 10.1371/journal.pone.0211513. eCollection 2019.
Anaplastic oligodendroglioma is a rare disease with an inadequately understood prognosis. The aim of this study was to investigate factors associated with survival outcome in anaplastic oligodendroglioma patients. A population-based cohort study was conducted based on the Surveillance, Epidemiology, and End Results program. In total, 1899 patients with a histological diagnosis of anaplastic oligodendroglioma from 1973 to 2015 were included. Mean age at diagnosis was 49.2 years, and 56.19% were male. In our study, 62.40% of patients were married, and 87.05% were white. Most patients (90.42%) were diagnosed with anaplastic oligodendroglioma as their first malignant primary tumor, but 9.58% had a diagnosis of at least one other primary malignancy; 87.89% of patients had received cancer-directed surgery. Patients receiving surgery had a better prognosis for overall survival compared to those not receiving surgery after propensity score matching analysis (p<0.05). The overall 1-, 3-, 5-, and 10-year survival of anaplastic oligodendroglioma was 78.7%, 60%, 50.2%, and 36.2%, respectively. Kaplan-Meier analysis indicated that age, marital status, presence of multiple primary malignancies, and surgical treatment were associated with overall survival, whereas sex and race were not. Moreover, age at diagnosis of 52 years was calculated as an optimal cutoff value to distinguish better and worse overall survival. Multivariate Cox proportional hazard analysis indicated that older age (OR 1.040, 95%CI1.035-1.045), single patients (OR 1.293, 95%CI 1.103-1.515), and presence of multiple primary malignancies (OR 1.501, 95%CI 1.238-1.820) were significantly associated with worse overall survival, whereas surgery (OR 0.584, 95%CI 0.494-0.689) was associated with better overall survival. A nomogram predicting 5-, and 10-year survival probability for anaplastic oligodendroglioma was constructed based on these variables. In conclusion, age, marital status, presence of multiple primary malignancies, and surgical treatment were associated with survival of anaplastic oligodendroglioma.
间变性少突胶质细胞瘤是一种罕见疾病，其预后尚未完全被理解。本研究的目的是探讨与间变性少突胶质细胞瘤患者生存结果相关的因素。这项基于监测、流行病学和最终结果（SEER）计划的人群队列研究共纳入了 1973 年至 2015 年间 1899 名组织学诊断为间变性少突胶质细胞瘤的患者。诊断时的平均年龄为 49.2 岁，56.19%为男性。在本研究中，62.40%的患者已婚，87.05%为白人。大多数患者（90.42%）被诊断为间变性少突胶质细胞瘤作为其首次恶性原发性肿瘤，但 9.58%有至少一次其他原发性恶性肿瘤的诊断；87.89%的患者接受了癌症定向手术。与未接受手术的患者相比，接受手术的患者在总生存方面预后更好，经倾向评分匹配分析后差异有统计学意义（p<0.05）。间变性少突胶质细胞瘤的总 1 年、3 年、5 年和 10 年生存率分别为 78.7%、60%、50.2%和 36.2%。Kaplan-Meier 分析表明，年龄、婚姻状况、是否存在多个原发性恶性肿瘤和手术治疗与总生存相关，而性别和种族则无关。此外，52 岁的诊断年龄被计算为区分更好和更差总生存的最佳截断值。多变量 Cox 比例风险分析表明，年龄较大（OR 1.040，95%CI 1.035-1.045）、单身患者（OR 1.293，95%CI 1.103-1.515）和存在多个原发性恶性肿瘤（OR 1.501，95%CI 1.238-1.820）与较差的总生存显著相关，而手术（OR 0.584，95%CI 0.494-0.689）与较好的总生存相关。基于这些变量，构建了预测间变性少突胶质细胞瘤 5 年和 10 年生存率的列线图。总之，年龄、婚姻状况、是否存在多个原发性恶性肿瘤和手术治疗与间变性少突胶质细胞瘤的生存相关。
