Wall M E, Wani M C, Manikumar G, Abraham P, Taylor H, Hughes T J, Warner J, McGivney R
Research Triangle Institute, Research Triangle Park, North Carolina 22709.
J Nat Prod. 1988 Nov-Dec;51(6):1084-91. doi: 10.1021/np50060a006.
A number of known prenylated flavonoids were isolated from Psoralea corylifolia using an assay procedure based on inhibition of the mutagenic action of 2-aminoanthracene on Salmonella typhimurium (T-98). All of these compounds were toxic rather than antimutagenic or desmutagenic. Bakuchiol [17], a known prenylated phenolic terpene, was also isolated; its activity was not due to toxicity. Biochanin A [4], a known isoflavone, was similarly isolated from Cicer arientinum and was active and nontoxic. Some of the above flavonoids were studied for inhibition of the mutagenicity of several different mutagens with results depending upon the structure of the flavonoid and the mutagen.
采用基于抑制2-氨基蒽对鼠伤寒沙门氏菌（T-98）诱变作用的检测方法，从补骨脂中分离出多种已知的异戊烯基化黄酮类化合物。所有这些化合物均具有毒性，而非抗诱变或去诱变作用。还分离出了已知的异戊烯基化酚类萜烯补骨脂酚[17]；其活性并非由毒性引起。已知的异黄酮染料木素[4]同样从鹰嘴豆中分离得到，且具有活性且无毒。对上述一些黄酮类化合物进行了抑制几种不同诱变剂诱变性的研究，结果取决于黄酮类化合物的结构和诱变剂。
