Wall M E, Wani M C, Gaetano K, Manikumar G, Taylor H, McGivney R
Research Triangle Institute, Research Triangle Park, North Carolina 27709.
J Nat Prod. 1988 Nov-Dec;51(6):1226-31. doi: 10.1021/np50060a028.
Maesol, a novel dimeric phenol, was isolated from seeds of Maesa montana and Maesa indica. Maesol was shown to have the formula C28H42O4 with structure 1, a dimeric, symmetrical 1,12-bis(3,3'-dihydroxy-4,4'-dimethyl-5,5'-dimethoxyphenyl)dodecane. It is the first compound with such structure to be isolated from plant material. Structure elucidation was based largely on 1H- and 13C-nmr techniques and comparison with a known synthetic isomeric dimer 3. Although crude extracts showed strong inhibition of 2-aminoanthracene activity against Salmonella typhimurium (T-98), the pure compound was inactive when tested for inhibition of the mutagenic activity of several mutagens.
新酚类化合物梅索酚（Maesol）是从山地密花树（Maesa montana）和印度密花树（Maesa indica）的种子中分离出来的。梅索酚的分子式为C28H42O4，其结构如结构1所示，是一种二聚体对称的1,12 - 双（3,3'-二羟基-4,4'-二甲基-5,5'-二甲氧基苯基）十二烷。它是从植物材料中分离得到的具有这种结构的首个化合物。结构解析主要基于1H - 和13C - 核磁共振技术，并与已知的合成异构体二聚体3进行比较。尽管粗提物对2 - 氨基蒽对鼠伤寒沙门氏菌（T - 98）的活性有强烈抑制作用，但在测试其对几种诱变剂诱变活性的抑制作用时，该纯化合物没有活性。
