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心脏移植受者中的环孢素神经毒性。

Cyclosporin neurotoxicity in cardiac transplant recipients.

作者信息

Lane R J, Roche S W, Leung A A, Greco A, Lange L S

机构信息

Regional Neurosciences Centre, Charing Cross Hospital, London, UK.

出版信息

J Neurol Neurosurg Psychiatry. 1988 Nov;51(11):1434-7. doi: 10.1136/jnnp.51.11.1434.

DOI:10.1136/jnnp.51.11.1434
PMID:3069960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1032815/
Abstract

Cyclosporin toxicity may produce a wide range of neurological disorders. We report three patients whose neurological problems developed while taking cyclosporin following cardiac transplantation, but resolved rapidly when the drug was discontinued. In two cases, MRI revealed abnormalities which disappeared with clinical recovery. Blood cyclosporin concentrations were not markedly increased, and it is possible that the neurotoxic effects of cyclosporin are mediated by metabolites, through an effect on the blood-brain barrier.

摘要

环孢素毒性可能会引发多种神经系统疾病。我们报告了三名患者，他们在心脏移植后服用环孢素期间出现了神经问题，但在停药后迅速得到缓解。在两例病例中，磁共振成像（MRI）显示的异常情况随着临床症状的恢复而消失。血液中环孢素浓度并未显著升高，环孢素的神经毒性作用有可能是由其代谢产物通过影响血脑屏障介导的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d45/1032815/886de2cfdc63/jnnpsyc00546-0064-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d45/1032815/6f087bfb574c/jnnpsyc00546-0063-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d45/1032815/886de2cfdc63/jnnpsyc00546-0064-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d45/1032815/6f087bfb574c/jnnpsyc00546-0063-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d45/1032815/886de2cfdc63/jnnpsyc00546-0064-a.jpg

相似文献

1
Cyclosporin neurotoxicity in cardiac transplant recipients.心脏移植受者中的环孢素神经毒性。
J Neurol Neurosurg Psychiatry. 1988 Nov;51(11):1434-7. doi: 10.1136/jnnp.51.11.1434.
2
Cyclosporin neurotoxicity in cardiac transplant recipient.心脏移植受者中的环孢素神经毒性
J Neurol Neurosurg Psychiatry. 1989 Jun;52(6):813. doi: 10.1136/jnnp.52.6.813.
3
Association between cyclosporin neurotoxicity and hypomagnesaemia.环孢素神经毒性与低镁血症之间的关联。
Lancet. 1984 Nov 17;2(8412):1116-20. doi: 10.1016/s0140-6736(84)91556-3.
4
Cyclosporin neurotoxicity in patients treated with allogeneic bone marrow transplantation.接受同种异体骨髓移植患者的环孢素神经毒性。
Biomed Pharmacother. 1986;40(4):148-50.
5
Cyclosporin A-induced reversible cortical blindness.
J Clin Neuroophthalmol. 1988 Dec;8(4):215-20.
6
Cyclosporin neurotoxicity presenting as an unilateral foot drop in a renal transplant patient.环孢素神经毒性表现为一名肾移植患者单侧足下垂。
Nephron. 1991;58(1):116. doi: 10.1159/000186392.
7
[Arterial hypertension in heart transplant recipients].[心脏移植受者的动脉高血压]
Presse Med. 1990;19(1):26-9.
8
[Infections in the heart transplant patient treated with cyclosporin A].[接受环孢素A治疗的心脏移植患者的感染情况]
Rev Esp Cardiol. 1987;40 Suppl 2:84-8.
9
[Pulmonary thromboembolism during cyclosporin immunosuppressive treatment in a heart transplant patient].[心脏移植患者接受环孢素免疫抑制治疗期间发生的肺血栓栓塞]
Med Clin (Barc). 1991 Feb 9;96(5):197.
10
Generalised epileptic fits in renal transplant recipients given cyclosporin A.接受环孢素A治疗的肾移植受者出现全身性癫痫发作。
Br Med J (Clin Res Ed). 1984 Nov 17;289(6455):1347-8. doi: 10.1136/bmj.289.6455.1347.

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Doc Ophthalmol. 2022 Dec;145(3):197-209. doi: 10.1007/s10633-022-09898-4. Epub 2022 Oct 26.
2
Neurologic Complications of Transplantation.移植的神经系统并发症。
Neurocrit Care. 2018 Feb;28(1):4-11. doi: 10.1007/s12028-017-0387-6.
3
Psychometric assessment of cardiac transplantation candidates.心脏移植候选者的心理测量评估。

本文引用的文献

1
Generalised epileptic fits in renal transplant recipients given cyclosporin A.接受环孢素A治疗的肾移植受者出现全身性癫痫发作。
Br Med J (Clin Res Ed). 1984 Nov 17;289(6455):1347-8. doi: 10.1136/bmj.289.6455.1347.
2
Targeted blood levels of cyclosporin for cardiac transplantation.
J Thorac Cardiovasc Surg. 1984 Dec;88(6):952-7.
3
Cyclosporine-associated central-nervous-system toxicity after allogeneic bone-marrow transplantation.异基因骨髓移植后环孢素相关的中枢神经系统毒性
N Engl J Med. 1984 Feb 23;310(8):527. doi: 10.1056/NEJM198402233100815.
J Clin Psychol Med Settings. 1994 Jun;1(2):135-47. doi: 10.1007/BF01999742.
4
Current status of psychological research in organ transplantation.器官移植心理研究的现状
J Clin Psychol Med Settings. 1994 Mar;1(1):41-70. doi: 10.1007/BF01991724.
5
Variable incidence of cyclosporine and FK-506 neurotoxicity in hematopoeitic malignancies and marrow conditions after allogeneic bone marrow transplantation.异基因骨髓移植后，造血系统恶性肿瘤和骨髓疾病中环孢素和FK - 506神经毒性的发生率各异。
Neurocrit Care. 2005;3(1):33-45. doi: 10.1385/NCC:3:1:033.
6
Pretransplantation conditioning influence on the occurrence of cyclosporine or FK-506 neurotoxicity in allogeneic bone marrow transplantation.移植前预处理对异基因骨髓移植中环孢素或FK-506神经毒性发生的影响。
AJNR Am J Neuroradiol. 2004 Feb;25(2):261-9.
7
Etiology of cortical and white matter lesions in cyclosporin-A and FK-506 neurotoxicity.环孢素A和FK-506神经毒性中皮质和白质病变的病因学。
AJNR Am J Neuroradiol. 2001 Nov-Dec;22(10):1901-14.
8
Quantitative MR diffusion mapping and cyclosporine-induced neurotoxicity.定量磁共振扩散成像与环孢素诱导的神经毒性
AJNR Am J Neuroradiol. 1999 Sep;20(8):1507-10.
9
CNS aspergillosis in organ transplantation: a clinicopathological study.器官移植中的中枢神经系统曲霉病：一项临床病理研究。
J Neurol Neurosurg Psychiatry. 1993 Feb;56(2):188-93. doi: 10.1136/jnnp.56.2.188.
10
Progressive visual deterioration leading to blindness after pediatric heart transplantation.小儿心脏移植术后渐进性视力减退导致失明。
Tex Heart Inst J. 1993;20(4):299-303.
4
Association between cyclosporin neurotoxicity and hypomagnesaemia.环孢素神经毒性与低镁血症之间的关联。
Lancet. 1984 Nov 17;2(8412):1116-20. doi: 10.1016/s0140-6736(84)91556-3.
5
Convulsions associated with cyclosporin A in renal transplant recipients.肾移植受者中与环孢素A相关的惊厥
Br Med J (Clin Res Ed). 1985 Feb 16;290(6467):555. doi: 10.1136/bmj.290.6467.555-a.
6
Cerebral blindness and encephalopathy with cyclosporin A toxicity.环孢素A毒性导致的脑盲和脑病
Neurology. 1987 Jun;37(6):1072-6. doi: 10.1212/wnl.37.6.1072.
7
Cyclosporin metabolites and central-nervous-system toxicity.环孢素代谢产物与中枢神经系统毒性
Lancet. 1988 May 28;1(8596):1223. doi: 10.1016/s0140-6736(88)92037-5.
8
Disturbance of blood-brain barrier after bone-marrow transplantation.骨髓移植后血脑屏障的紊乱。
Lancet. 1985 Aug 3;2(8449):280-1. doi: 10.1016/s0140-6736(85)90335-6.
9
Severe central-nervous-system toxicity associated with cyclosporin.与环孢素相关的严重中枢神经系统毒性。
Lancet. 1985 Jan 26;1(8422):219-20. doi: 10.1016/s0140-6736(85)92053-7.
10
Cyclosporin-associated fatal convulsions.环孢素相关的致命性惊厥。
Lancet. 1985 Jan 26;1(8422):219. doi: 10.1016/s0140-6736(85)92052-5.