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环孢素A毒性导致的脑盲和脑病

Cerebral blindness and encephalopathy with cyclosporin A toxicity.

作者信息

Rubin A M, Kang H

出版信息

Neurology. 1987 Jun;37(6):1072-6. doi: 10.1212/wnl.37.6.1072.

DOI:10.1212/wnl.37.6.1072
PMID:3587633
Abstract

We observed acute cerebral blindness and encephalopathy complicating cyclosporin A (CyA) toxicity in a 5-year-old transplantation patient. Serum CyA level was 1,704 ng/ml (normal, less than 300 ng/ml). Additional neurologic complications of CyA toxicity will be reviewed.

摘要

我们在一名5岁的移植患者中观察到急性脑盲和脑病并发环孢素A（CyA）毒性。血清CyA水平为1704 ng/ml（正常范围小于300 ng/ml）。将对CyA毒性的其他神经系统并发症进行综述。

相似文献

1
Cerebral blindness and encephalopathy with cyclosporin A toxicity.环孢素A毒性导致的脑盲和脑病
Neurology. 1987 Jun;37(6):1072-6. doi: 10.1212/wnl.37.6.1072.
2
[Cortical blindness during treatment with cyclosporin].[环孢素治疗期间的皮质盲]
Ned Tijdschr Geneeskd. 1994 Oct 8;138(41):2057-61.
3
Cyclosporin-associated cerebral lesions in liver transplantation.肝移植中环孢素相关的脑部病变
Lancet. 1988 Jun 25;1(8600):1457. doi: 10.1016/s0140-6736(88)92263-5.
4
Severe central-nervous-system toxicity associated with cyclosporin.与环孢素相关的严重中枢神经系统毒性。
Lancet. 1985 Jan 26;1(8422):219-20. doi: 10.1016/s0140-6736(85)92053-7.
5
Dosage of Cyclosporin A in children with renal transplants.
Clin Nephrol. 1984 Aug;22(2):68-71.
6
Complex partial status epilepticus associated with cyclosporin A therapy.与环孢素A治疗相关的复杂部分性癫痫持续状态。
J Neurol Neurosurg Psychiatry. 1989 Sep;52(9):1068-71. doi: 10.1136/jnnp.52.9.1068.
7
Cyclosporin A in marrow transplantation for leukemia and aplastic anemia.
Exp Hematol. 1985 May;13(4):244-8.
8
Cortical blindness due to cyclosporin.环孢素导致的皮质盲
Neth J Med. 1993 Aug;43(1-2):69-70.
9
Cyclosporin A-induced reversible cortical blindness.
J Clin Neuroophthalmol. 1988 Dec;8(4):215-20.
10
[Reversible posterior leukoencephalopathy in a patient receiving cyclosporin therapy].
Rinsho Shinkeigaku. 1999 Feb-Mar;39(2-3):360-3.

引用本文的文献

1
Current status of psychological research in organ transplantation.器官移植心理研究的现状
J Clin Psychol Med Settings. 1994 Mar;1(1):41-70. doi: 10.1007/BF01991724.
2
[Demyelinating disorders].[脱髓鞘疾病]
Nervenarzt. 2010 Apr;81(4):471-96. doi: 10.1007/s00115-010-2948-1.
3
Neuropsychiatric complications after liver transplantation: role of immunosuppression and hepatitis C.肝移植后的神经精神并发症：免疫抑制和丙型肝炎的作用
Dig Dis Sci. 2006 Jun;51(6):1079-81. doi: 10.1007/s10620-006-8012-0.
4
Variable incidence of cyclosporine and FK-506 neurotoxicity in hematopoeitic malignancies and marrow conditions after allogeneic bone marrow transplantation.异基因骨髓移植后，造血系统恶性肿瘤和骨髓疾病中环孢素和FK - 506神经毒性的发生率各异。
Neurocrit Care. 2005;3(1):33-45. doi: 10.1385/NCC:3:1:033.
5
Pretransplantation conditioning influence on the occurrence of cyclosporine or FK-506 neurotoxicity in allogeneic bone marrow transplantation.移植前预处理对异基因骨髓移植中环孢素或FK-506神经毒性发生的影响。
AJNR Am J Neuroradiol. 2004 Feb;25(2):261-9.
6
Etiology of cortical and white matter lesions in cyclosporin-A and FK-506 neurotoxicity.环孢素A和FK-506神经毒性中皮质和白质病变的病因学。
AJNR Am J Neuroradiol. 2001 Nov-Dec;22(10):1901-14.
7
Increased incidence of neurological complications in patients receiving an allogenic bone marrow transplantation from alternative donors.接受来自替代供体的同种异体骨髓移植的患者出现神经并发症的发生率增加。
J Neurol Neurosurg Psychiatry. 2000 Jan;68(1):36-40. doi: 10.1136/jnnp.68.1.36.
8
Quantitative MR diffusion mapping and cyclosporine-induced neurotoxicity.定量磁共振扩散成像与环孢素诱导的神经毒性
AJNR Am J Neuroradiol. 1999 Sep;20(8):1507-10.
9
Delayed, transient encephalopathy after marrow transplantation: case reports and MRI findings in four patients.骨髓移植后迟发性短暂性脑病：4例患者的病例报告及MRI表现
J Neurooncol. 1996 Mar;27(3):241-50. doi: 10.1007/BF00165481.
10
Acute leucoencephalopathy during cyclosporin A therapy in a patient with nephrotic syndrome.一名肾病综合征患者在接受环孢素A治疗期间发生急性白质脑病。
Pediatr Nephrol. 1994 Aug;8(4):483-5. doi: 10.1007/BF00856540.