Child Study Center, Yale School of Medicine, 230 S. Frontage Rd., New Haven, CT 06520, United States.
Child Study Center, Yale School of Medicine, 230 S. Frontage Rd., New Haven, CT 06520, United States; Departments of Psychiatry and Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, United States.
J Affect Disord. 2019 Feb 15;245:806-811. doi: 10.1016/j.jad.2018.11.070. Epub 2018 Nov 14.
Anxious youth are at risk for negative peer interactions including peer victimization, and for suicidal ideation. However, data about the pattern of association between these two factors are scarce. In this study we examined the association between negative peer interactions and suicidal ideation in a sample of children and adolescents with anxiety disorders, and whether oxytocin, which has been shown to enhance the impact of social events, moderates the impact of negative peer interactions on suicidal ideation.
Participants were 168 youths with primary anxiety disorders. All participants were assessed with semi-structured diagnostic interviews, and with self-report measures of suicidal ideation, negative peer interactions, anxiety, and depression. The anxious youths' salivary oxytocin levels were measured with immunoassay.
Thirty percent of the anxious youths reported suicidal ideation, with suicidal ideation severity associated with negative peer social interactions and depressive symptoms. Consistent with past data indicating that oxytocin enhances the impact of social events, the association between peer negative social interactions and suicidal ideation was stronger in youths with high oxytocin levels than in youths with low levels (i.e., moderation).
Assessment focused on suicidal ideation and data on suicidal behavior were not available. Limitations inherent to immunoassay measurement of peripheral oxytocin levels are noted.
Negative peer interactions are associated with suicidal ideation in youth with anxiety disorders, and the association is stronger in youth with high oxytocin levels.
焦虑的年轻人面临着负面的同伴互动的风险，包括同伴侵害和自杀意念。然而，关于这两个因素之间关联模式的数据却很少。在这项研究中，我们在一组患有焦虑症的儿童和青少年中检查了负向同伴互动与自杀意念之间的关联，以及已经表明可以增强社交事件影响的催产素是否会调节负向同伴互动对自杀意念的影响。
参与者是 168 名患有原发性焦虑症的青少年。所有参与者都接受了半结构化的诊断访谈，并接受了自杀意念、负向同伴互动、焦虑和抑郁的自我报告评估。通过免疫测定法测量了焦虑青少年的唾液催产素水平。
30%的焦虑青少年报告了自杀意念，自杀意念的严重程度与负向同伴社交互动和抑郁症状有关。与过去的数据一致，表明催产素增强了社交事件的影响，在高催产素水平的青少年中，同伴负向社交互动与自杀意念之间的关联比低催产素水平的青少年更强（即调节作用）。
评估集中在自杀意念上，并且没有关于自杀行为的数据。注意到外周催产素水平的免疫测定测量固有的局限性。
负向同伴互动与患有焦虑症的年轻人的自杀意念有关，而在催产素水平较高的年轻人中，这种关联更强。
