Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Department of Psychology, University of Pittsburgh, 210 S. Bouquet St., Pittsburgh, PA, USA.
Child Psychiatry Hum Dev. 2020 Apr;51(2):163-173. doi: 10.1007/s10578-019-00920-6.
Suicidal ideation increases in adolescence, especially for anxious youth, and is a frequent precursor to suicide. This study examined whether neural processing of social rejection interacted with negative social experiences to predict suicidal ideation. Thus, to our knowledge this is the first study to examine how brain function may interact with the environment to contribute to suicidal ideation in youth, consistent with a developmental psychopathology perspective. Thirty-six anxious youth (ages 11 to 16) completed diagnostic interviews and questionnaires, an ecological momentary assessment (EMA) protocol, and a functional magnetic resonance imaging paradigm. Results showed that youth experienced greater severity of suicidal ideation when they exhibited heightened activation to social rejection in the right anterior insula and also experienced high levels of peer victimization or EMA-measured daily negative social experiences. Findings provide preliminary evidence that alterations in neural processing of social rejection interacts with exposure to negative social experiences to contribute to suicidal ideation.
自杀意念在青少年中增加，特别是对于焦虑的年轻人，并且是自杀的常见前兆。本研究探讨了社会排斥的神经处理是否与负面社会经历相互作用，从而预测自杀意念。因此，据我们所知，这是第一项研究大脑功能如何与环境相互作用，从而导致青少年自杀意念的研究，这与发展心理病理学的观点一致。36 名焦虑的年轻人（年龄在 11 至 16 岁之间）完成了诊断访谈和问卷调查、生态瞬时评估 (EMA) 方案以及功能磁共振成像范式。结果表明，当右前岛叶显示出对社会排斥的高度激活，并且经历了高水平的同伴受害或 EMA 测量的日常负面社会经历时，年轻人经历了更严重的自杀意念。研究结果初步表明，社会排斥的神经处理的改变与负面社会经历的暴露相互作用，从而导致自杀意念。
