Mt. Hope Family Center, University of Rochester, 187 Edinburgh Street, Rochester, NY 14608, United States.
Mt. Hope Family Center, University of Rochester, 187 Edinburgh Street, Rochester, NY 14608, United States.
J Affect Disord. 2019 Oct 1;257:421-427. doi: 10.1016/j.jad.2019.06.051. Epub 2019 Jul 2.
Suicide ideation and behavior remains a significant public policy concern. The interpersonal-psychological theory of suicide posits that thwarted belongingness potentiates risk for suicide. Early disruptions in caregiving have documented effects on lifespan social and interpersonal development, and therefore warrants further investigation in suicide research. This novel study investigates risk for suicide ideation conferred by infant-onset child maltreatment and oxytocin genotypes (OXTR and CD38) and tests interactive effects of genetics and early maltreatment experiences.
Participants (N = 251) were from a longitudinal follow-up study of emerging adults who participated in a research summer camp program as children (wave 1). Childhood maltreatment was coded from child protective service records and buccal cells were obtained from children and genotyped. At wave 2, self-reported suicide ideation and internalizing symptomatology were obtained.
Maltreatment onset in infancy was significantly related to lifetime suicide ideation. The CD38 gene variation moderated this association such that early onset maltreatment was related to suicide ideation among C-carriers only. The OXTR gene did not relate to lifetime suicide ideation, nor did it moderate early onset maltreatment risk.
This study was conducted with a relatively small sample, necessitating the combination of genotypes into binary groups. Replication is necessary.
Child maltreatment experienced early in development confers significant risk for lifetime suicide ideation. Furthermore, greater risk for suicide ideation was present for those with specific oxytocin genotypes. These findings further emphasize the importance of preventive interventions aimed at decreasing the incidence of maltreatment and increasing support for high risk families.
自杀意念和行为仍然是一个重大的公共政策问题。自杀的人际心理理论认为，归属感受挫会增加自杀的风险。有研究记录表明，早期的照顾中断对寿命的社会和人际关系发展有影响，因此值得在自杀研究中进一步调查。这项新的研究调查了婴儿期发生的儿童虐待和催产素基因（OXTR 和 CD38）对自杀意念风险的影响，并测试了遗传和早期虐待经历的相互作用。
参与者（N=251）来自一项对成年早期个体的纵向随访研究，他们曾作为儿童参加过研究夏令营项目（第 1 波）。儿童保护服务记录中记录了儿童期虐待情况，并从儿童身上获取口腔细胞进行基因分型。在第 2 波，我们获得了自我报告的自杀意念和内化症状。
婴儿期虐待的发生与终生自杀意念显著相关。CD38 基因变异对此关联具有调节作用，即早期发生的虐待仅与 C 携带者的自杀意念有关。OXTR 基因与终生自杀意念无关，也不能调节早期发生的虐待风险。
这项研究的样本相对较小，需要将基因型组合成二进制组。需要进行复制。
早期发展过程中的儿童虐待会给终生自杀意念带来重大风险。此外，对于具有特定催产素基因型的个体，自杀意念的风险更高。这些发现进一步强调了旨在减少虐待发生率和增加高危家庭支持的预防干预的重要性。
