a Biomedical and Life Sciences, Faculty of Health and Medicine , Lancaster University , Lancaster , UK.
b Institute of Healthy Ageing, Genetics, Evolution & Environment , University College London , London , UK.
Autophagy. 2019 Apr;15(4):731-732. doi: 10.1080/15548627.2019.1569919. Epub 2019 Jan 30.
A plethora of studies over several decades has demonstrated the importance of autophagy in aging and age-related neurodegenerative disease. The role of autophagy in damage clearance and cell survival is well established, and supports a prevailing view that increasing autophagic activity can be broadly beneficial, and could form the basis of anti-aging interventions. However, macroautophagy/autophagy also promotes some elements of senescence. For example, in C. elegans hermaphrodites it facilitates conversion of intestinal biomass into yolk, leading to sex-specific gut atrophy and senescent steatosis.
几十年来的大量研究表明自噬在衰老和与年龄相关的神经退行性疾病中的重要性。自噬在清除损伤和细胞存活中的作用已得到充分证实，并支持这样一种流行观点，即增加自噬活性可能具有广泛的益处，并可能成为抗衰老干预的基础。然而，巨自噬/自噬也促进了衰老的某些方面。例如，在秀丽隐杆线虫的雌雄同体中，它促进了肠道生物质转化为卵黄，导致特定于性别的肠道萎缩和衰老性脂肪变性。
