Ding Feng, Zhao Yan
School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.
Department of Bioengineering, Harbin Institute of Technology, Weihai 264209, China.
Antioxidants (Basel). 2022 Oct 27;11(11):2115. doi: 10.3390/antiox11112115.
Astaxanthin is a marine xanthophyll carotenoid which effectively prevents intracellular oxidative stress and has beneficial effects against various human diseases. It has been shown that astaxanthin protects () from oxidative damages and extends the lifespan of possibly by modulating genes involved in insulin/insulin-like growth factor (IGF) signaling (IIS) and the oxidoreductase system, although the exact mechanisms remain elusive. In this study, RNA sequencing analyses were employed to identify the differentially expressed genes in in response to astaxanthin treatment. A total of 190 mRNAs and 6 microRNAs (miRNAs) were significantly changed by astaxanthin treatment in . Gene ontology (GO) term and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses indicated that the mRNAs and miRNAs significantly altered by astaxanthin mainly function in innate immunity, lipid metabolism and stress responses, a significant portion of which are related to lifespan regulation in . The study revealed novel mRNA and miRNA targets of astaxanthin, providing new insights for understanding the anti-aging mechanisms and the biological function of astaxanthin.
虾青素是一种海洋叶黄素类胡萝卜素，能有效预防细胞内氧化应激，并对多种人类疾病具有有益作用。研究表明，虾青素可保护（此处原文缺失相关内容）免受氧化损伤，并可能通过调节参与胰岛素/胰岛素样生长因子（IGF）信号通路（IIS）和氧化还原酶系统的基因来延长（此处原文缺失相关内容）的寿命，尽管确切机制仍不清楚。在本研究中，采用RNA测序分析来鉴定（此处原文缺失相关内容）中响应虾青素处理的差异表达基因。虾青素处理使（此处原文缺失相关内容）中总共190个mRNA和6个 microRNA（miRNA）发生了显著变化。基因本体（GO）术语和京都基因与基因组百科全书（KEGG）通路分析表明，虾青素显著改变的mRNA和miRNA主要在先天免疫、脂质代谢和应激反应中发挥作用，其中很大一部分与（此处原文缺失相关内容）的寿命调节有关。该研究揭示了虾青素新的mRNA和miRNA靶点，为理解虾青素的抗衰老机制和生物学功能提供了新的见解。
