肿瘤丙酮酸激酶M2：一种有前景的胃肠道癌分子靶点。
Tumor pyruvate kinase M2: A promising molecular target of gastrointestinal cancer.
作者信息
Guo Chen, Li Guan, Hou Jianing, Deng Xingming, Ao Sheng, Li Zhuofei, Lyu Guoqing
机构信息
Department of Biology, Southern University of Science and Technology, Shenzhen 518055, China.
Department of Gastrointestinal Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.
出版信息
Chin J Cancer Res. 2018 Dec;30(6):669-676. doi: 10.21147/j.issn.1000-9604.2018.06.11.
Gastrointestinal (GI) cancer is one of the most common causes of cancer-related deaths worldwide. Tumor markers are valuable in detecting post-surgical recurrence or in monitoring response to chemotherapy. Pyruvate kinase isoform M2 (PKM2), a glycolytic enzyme catalyzing conversion of phosphoenolpyruvate (PEP) to pyruvate, confers a growth advantage to the tumor cells and enables them to adapt to the tumor microenvironment. In this review, we have summarized current research on the expression and regulation of PKM2 in tumor cells, and its potential role in GI carcinogenesis and progression. Furthermore, we have also discussed the potential of PKM2 as a diagnostic and screening marker, and a therapeutic target in GI cancer.
胃肠道（GI）癌是全球癌症相关死亡的最常见原因之一。肿瘤标志物在检测术后复发或监测化疗反应方面具有重要价值。丙酮酸激酶同工酶M2（PKM2）是一种催化磷酸烯醇丙酮酸（PEP）转化为丙酮酸的糖酵解酶，赋予肿瘤细胞生长优势并使其能够适应肿瘤微环境。在本综述中，我们总结了目前关于PKM2在肿瘤细胞中的表达和调控及其在胃肠道癌发生和进展中的潜在作用的研究。此外，我们还讨论了PKM2作为胃肠道癌诊断和筛查标志物以及治疗靶点的潜力。
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