Varma Ross, Szilagyi Sandor, Harshan Manju
Department of Radiology, Mount Sinai West, 1000 Tenth Avenue, NY 10019, New York, USA.
Department of Radiology, Mount Sinai Beth Israel, 10 Nathan D Perlman Pl, NY 10003, New York, USA.
Radiol Case Rep. 2019 Jan 17;14(4):430-435. doi: 10.1016/j.radcr.2019.01.001. eCollection 2019 Apr.
To date, mammographic involvement in mixed connective tissue disease has not been described in the literature to the authors' knowledge. In addition, only 2 case reports have described panniculitis in mixed connective tissue disease. We present a patient with mixed connective tissue disease with coarse sheet-like calcifications on mammography bilaterally, which increased over time corresponding to rise in levels of anti-dsDNA. Biopsy showed fat necrosis with calcifications, chronic inflammation and fibrosis, vasculitis, as well as CD3, CD4, and CD8+ T cells and CD20+ B cells. These findings are similar histologically and mammographically to "lupus mastitis."
