Carion Alessandra, Hétru Julie, Markey Angèle, Suarez-Ulloa Victoria, Frédéric Silvestre
Laboratory of Evolutionary and Adaptive Physiology, Institute of Life, Earth and Environment, University of Namur, Namur, Belgium.
J Xenobiot. 2018 Oct 29;8(1):7820. doi: 10.4081/xeno.2018.7820. eCollection 2018 Oct 20.
Mangrove rivulus, , is a hermaphrodite fish capable of self-fertilization. This particularity allows to naturally produce highly homozygous and isogenic individuals. Despite the low genetic diversity, rivulus can live in extremely variable environments and adjust its phenotype accordingly. This species represents a unique opportunity to clearly distinguish the genetic and non-genetic factors implicated in adaptation and evolution, such as epigenetic mechanisms. It is thus a great model in aquatic ecotoxicology to investigate the effects of xenobiotics on the epigenome, and their potential long-term impacts. In the present study, we used the mangrove rivulus to investigate the effects of the neurotoxin b-N-methylamino-L-alanine (BMAA) on larvae behaviors after 7 days exposure to two sub-lethal concentrations. Results show that BMAA can affect the maximal speed and prey capture (trials and failures), suggesting potential impacts on the organism's fitness.
红树鳉鱼（Kryptolebias marmoratus）是一种能够自我受精的雌雄同体鱼类。这种特性使其能够自然产生高度纯合且同基因的个体。尽管遗传多样性较低，但红树鳉鱼能够生活在极端多变的环境中，并相应地调整其表型。该物种为清晰区分参与适应和进化的遗传和非遗传因素（如表观遗传机制）提供了独特的机会。因此，它是水生生态毒理学中研究外源性物质对表观基因组的影响及其潜在长期影响的绝佳模型。在本研究中，我们使用红树鳉鱼来研究神经毒素β-N-甲基氨基-L-丙氨酸（BMAA）在两种亚致死浓度下暴露7天后对幼虫行为的影响。结果表明，BMAA会影响最大速度和捕食（尝试和失败情况），这表明对生物体的适应性可能存在影响。
