Halper J, Fu S M, Wang C Y, Winchester R, Kunkel H G
J Immunol. 1978 May;120(5):1480-4.
The "Ia-like" antigens characteristically present on the membrane of B lymphocytes were shown to be absent in most terminally differentiated Ig-producing plasma cells. This was most evident in analyses of myeloma plasma cells that uniformly lacked the Ia-antigens. Also, in B lymphoid cell lines, the lymphoblasts were uniformly Ia-positive but the plasma cells were negative. In contrast, however, the majority of plasma cells produced after pokeweed mitogen stimulation remained positive. Plasma cells in tonsil and in the tissue of peripheral blood of patients with Wladenström's macroglobulinemia were also sometimes Ia-positive although the majority were negative. Studies of membrane IgM and IgD indicated a similar loss in some instances. However, the SIg and Ia antigens were not invariably associated. These results lead to the conclusion that Ia-antigens are differentiation antigens for B cells and are usually lost by the end stage cells in this series.
在大多数终末分化的产生免疫球蛋白的浆细胞中，特征性地存在于B淋巴细胞膜上的“Ia样”抗原被证明是缺失的。这在骨髓瘤浆细胞的分析中最为明显，骨髓瘤浆细胞均一地缺乏Ia抗原。同样，在B淋巴细胞系中，淋巴母细胞均一地Ia阳性，但浆细胞为阴性。然而，相比之下，商陆有丝分裂原刺激后产生的大多数浆细胞仍为阳性。华氏巨球蛋白血症患者扁桃体和外周血组织中的浆细胞有时也为Ia阳性，尽管大多数为阴性。对膜IgM和IgD的研究表明，在某些情况下也有类似的缺失。然而，表面免疫球蛋白（SIg）和Ia抗原并非总是相关联。这些结果得出结论，Ia抗原是B细胞的分化抗原，并且在该系列的终末阶段细胞中通常会丢失。
